Tiliacora triandra, an Anti-Intoxication Plant, Improves Memory Impairment, Neurodegeneration, Cholinergic Function, and Oxidative Stress in Hippocampus of Ethanol Dependence Rats
Joint Authors
Wattanathorn, Jintanaporn
Chaisiwamongkol, Kowit
Phunchago, Nattaporn
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress plays an important role in brain dysfunctions induced by alcohol.
Since less therapeutic agent against cognitive deficit and brain damage induced by chronic alcohol consumption is less available, we aimed to assess the effect of Tiliacora triandra extract, a plant possessing antioxidant activity, on memory impairment, neuron density, cholinergic function, and oxidative stress in hippocampus of alcoholic rats.
Male Wistar rats were induced ethanol dependence condition by semivoluntary intake of alcohol for 15 weeks.
Alcoholic rats were orally given T.
triandra at doses of 100, 200, and 400 mg·kg−1BW for 14 days.
Memory assessment was performed every 7 days while neuron density, activities of AChE, SOD, CAT, and GSH-Px and, MDA level in hippocampus were assessed at the end of study.
Interestingly, the extract mitigated the increased escape latency, AChE and MDA level.
The extract also mitigated the decreased retention time, SOD, CAT, and GSH-Px activities, and neurons density in hippocampus induced by alcohol.
These data suggested that the extract improved memory deficit in alcoholic rats partly via the decreased oxidative stress and the suppression of AChE.
Therefore, T.
triandra is the potential reagent for treating brain dysfunction induced by alcohol.
However, further researches are necessary to understand the detail mechanism and possible active ingredient.
American Psychological Association (APA)
Phunchago, Nattaporn& Wattanathorn, Jintanaporn& Chaisiwamongkol, Kowit. 2015. Tiliacora triandra, an Anti-Intoxication Plant, Improves Memory Impairment, Neurodegeneration, Cholinergic Function, and Oxidative Stress in Hippocampus of Ethanol Dependence Rats. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075810
Modern Language Association (MLA)
Phunchago, Nattaporn…[et al.]. Tiliacora triandra, an Anti-Intoxication Plant, Improves Memory Impairment, Neurodegeneration, Cholinergic Function, and Oxidative Stress in Hippocampus of Ethanol Dependence Rats. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075810
American Medical Association (AMA)
Phunchago, Nattaporn& Wattanathorn, Jintanaporn& Chaisiwamongkol, Kowit. Tiliacora triandra, an Anti-Intoxication Plant, Improves Memory Impairment, Neurodegeneration, Cholinergic Function, and Oxidative Stress in Hippocampus of Ethanol Dependence Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075810