Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis
Joint Authors
Rabelo, Luíza A.
Nunes-Souza, Valéria
Ferreira, Fernanda O.
Goulart, Marília Oliveira F.
Fonseca, Lucas José S. da
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Arginase is a metalloenzyme which hydrolyzes L-arginine to L-ornithine and urea.
Since its discovery, in the early 1900s, this enzyme has gained increasing attention, as literature reports have progressively pointed to its critical participation in regulating nitric oxide bioavailability.
Indeed, accumulating evidence in the following years would picture arginase as a key player in vascular health.
Recent studies have highlighted the arginase regulatory role in the progression of atherosclerosis, the latter an essentially prooxidant state.
Apart from the fact that arginase has been proven to impair different metabolic pathways, and also as a consequence of this, the repercussions of the actions of such enzyme go further than first thought.
In fact, such metalloenzyme exhibits direct implications in multiple cardiometabolic diseases, among which are hypertension, type 2 diabetes, and hypercholesterolemia.
Considering the epidemiological repercussions of these clinical conditions, arginase is currently seen under the spotlights of the search for developing specific inhibitors, in order to mitigate its deleterious effects.
That said, the present review focuses on the role of arginase in endothelial function and its participation in the establishment of atherosclerotic lesions, discussing the main regulatory mechanisms of the enzyme, also highlighting the potential development of pharmacological strategies in related cardiovascular diseases.
American Psychological Association (APA)
Rabelo, Luíza A.& Ferreira, Fernanda O.& Nunes-Souza, Valéria& Fonseca, Lucas José S. da& Goulart, Marília Oliveira F.. 2015. Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075811
Modern Language Association (MLA)
Rabelo, Luíza A.…[et al.]. Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075811
American Medical Association (AMA)
Rabelo, Luíza A.& Ferreira, Fernanda O.& Nunes-Souza, Valéria& Fonseca, Lucas José S. da& Goulart, Marília Oliveira F.. Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075811