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3-(3-Pyridylmethylidene)-2-indolinone Reduces the Severity of Colonic Injury in a Murine Model of Experimental Colitis
Joint Authors
Yang, Xi
Wang, Kun-Ping
Zhang, Chao
Zhang, Shou-Guo
Liu, En-Dong
Kong, Xiang-Zhen
Zhao, Ke
Zhan, Yi-Qun
Dong, Xiao-Ming
Ge, Chang-Hui
Yu, Miao
Chen, Hui
Wang, Lin
Yang, Xiao-Ming
Li, Chang-Yan
Cao, Peng
Hu, Chunping
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Nrf2 is the key transcription factor regulating the antioxidant response which is crucial for cytoprotection against extracellular stresses.
Numerous in vivo studies indicate that Nrf2 plays a protective role in anti-inflammatory response.
3-(3-Pyridylmethylidene)-2-indolinone (PMID) is a synthesized derivative of 2-indolinone compounds.
Our previous study suggested that PMID induces the activation of Nrf2/ARE pathway, then protecting against oxidative stress-mediated cell death.
However, little is known regarding the anti-inflammatory properties of PMID in severe inflammatory phenotypes.
In the present study we determined if PMID treatment protects mice from dextran sodium sulphate- (DSS-) induced colitis.
The result suggests that treatment with PMID prior to colitis induction significantly reduced body weight loss, shortened colon length, and decreased disease activity index compared to control mice.
Histopathological analysis of the colon revealed attenuated inflammation in PMID pretreated animals.
The levels of inflammatory markers in colon tissue and serum were reduced associated with inhibition of NF-κB activation.
The expression levels of Nrf2-dependent genes such as HO-1, NQO1, and Nrf2 were increased in PMID pretreated mice.
However, PMID pretreatment did not prevent DSS-induced colitis in Nrf2 knockout mice.
These data indicate that PMID pretreatment in mice confers protection against DSS-induced colitis in Nrf2-dependent manner, suggesting a potential role of PMID in anti-inflammatory response.
American Psychological Association (APA)
Wang, Kun-Ping& Zhang, Chao& Zhang, Shou-Guo& Liu, En-Dong& Yang, Xi& Kong, Xiang-Zhen…[et al.]. 2015. 3-(3-Pyridylmethylidene)-2-indolinone Reduces the Severity of Colonic Injury in a Murine Model of Experimental Colitis. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075821
Modern Language Association (MLA)
Wang, Kun-Ping…[et al.]. 3-(3-Pyridylmethylidene)-2-indolinone Reduces the Severity of Colonic Injury in a Murine Model of Experimental Colitis. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075821
American Medical Association (AMA)
Wang, Kun-Ping& Zhang, Chao& Zhang, Shou-Guo& Liu, En-Dong& Yang, Xi& Kong, Xiang-Zhen…[et al.]. 3-(3-Pyridylmethylidene)-2-indolinone Reduces the Severity of Colonic Injury in a Murine Model of Experimental Colitis. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075821