Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism
Joint Authors
Michalak, Krzysztof Piotr
Woźniak, Piotr
Maćkowska-Kędziora, Agnieszka
Sobolewski, Bogusław
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Glutamine (GLN) is commonly known as an important metabolite used for the growth of cancer cells but the effects of its intake in cancer patients are still not clear.
However, GLN is the main substrate for DNA and fatty acid synthesis.
On the other hand, it reduces the oxidative stress by glutathione synthesis stimulation, stops the process of cancer cachexia, and nourishes the immunological system and the intestine epithelium, as well.
The current paper deals with possible positive effects of GLN supplementation and conditions that should be fulfilled to obtain these effects.
The analysis of GLN metabolism suggests that the separation of GLN and carbohydrates in the diet can minimize simultaneous supply of ATP (from glucose) and NADPH2 (from glutamine) to cancer cells.
It should support to a larger extent the organism to fight against the cancer rather than the cancer cells.
GLN cannot be considered the effective source of ATP for cancers with the impaired oxidative phosphorylation and pyruvate dehydrogenase inhibition.
GLN intake restores decreased levels of glutathione in the case of chemotherapy and radiotherapy; thus, it facilitates regeneration processes of the intestine epithelium and immunological system.
American Psychological Association (APA)
Michalak, Krzysztof Piotr& Maćkowska-Kędziora, Agnieszka& Sobolewski, Bogusław& Woźniak, Piotr. 2015. Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075822
Modern Language Association (MLA)
Michalak, Krzysztof Piotr…[et al.]. Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1075822
American Medical Association (AMA)
Michalak, Krzysztof Piotr& Maćkowska-Kędziora, Agnieszka& Sobolewski, Bogusław& Woźniak, Piotr. Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075822
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075822