Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator
Joint Authors
Zeng, Zhenhua
Chen, Zhongqing
Xu, Siqi
Song, Rui
Yang, Hong
Zhao, Ke-seng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
To evaluate the role of SIRT1 in small intestine damage following severe hemorrhagic shock and to investigate whether polydatin (PD) can activate SIRT1 in shock treatment.
Research Design and Methods.
The severe hemorrhagic shock model was reproduced in Sprague Dawley rats.
Main Outcome Measures.
Two hours after drug administration, half of the rats were assessed for survival time evaluation and the remainder were used for small intestinal tissue sample collection.
Results.
Bleeding and swelling appeared in the small intestine with epithelial apoptosis and gut barrier disturbance during hemorrhagic shock.
SIRT1 activity and PGC-1α protein expression of the small intestine were decreased, which led to an increase in acetylated SOD2 and decreases in the expression and activity of SOD2, resulting in severe oxidative stress.
The decreased SIRT1 activity and expression were partially restored in the PD administration group, which showed reduced intestine injury and longer survival time.
Notably, the effect of PD was abolished after the addition of Ex527, a selective inhibitor of SIRT1.
Conclusions.
The results collectively suggest a role for the SIRT1-PGC-1α-SOD2 axis in small intestine injury following severe hemorrhagic shock and that PD is an effective SIRT1 activator for the shock treatment.
American Psychological Association (APA)
Zeng, Zhenhua& Chen, Zhongqing& Xu, Siqi& Song, Rui& Yang, Hong& Zhao, Ke-seng. 2015. Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075824
Modern Language Association (MLA)
Zeng, Zhenhua…[et al.]. Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075824
American Medical Association (AMA)
Zeng, Zhenhua& Chen, Zhongqing& Xu, Siqi& Song, Rui& Yang, Hong& Zhao, Ke-seng. Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075824
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075824