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Phase I Study of Anti-CD3 x Anti-Her2 Bispecific Antibody in Metastatic Castrate Resistant Prostate Cancer Patients
Joint Authors
Vaishampayan, Ulka
Thakur, Archana
Rathore, Ritesh
Kouttab, Nicola
Lum, Lawrence G.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
New nontoxic targeted approaches are needed for patients with castrate resistant prostate cancer (CRPC).
Our preclinical studies show that activated T cells (ATC) armed with anti-CD3 x anti-Her2 bispecific antibody (Her2Bi) kill prostate cancer cells lines, induce a Th1 cytokine pattern upon engagement of tumor cells, prevent the development of prostate tumors, and retard tumor growth in immunodeficient mice.
These studies provided strong rationale for our phase I dose-escalation pilot study to test ATC armed with Her2Bi (aATC) for safety in men with CRPC.
Methods.
Seven of 8 men with CRPC were evaluable after receiving two infusions per week for 4 weeks.
The men received 2.5, 5 or 10 × 109 aATC per infusion with low dose interleukin-2 and granulocyte-macrophage colony stimulating factor.
Results.
There were no dose limiting toxicities, and there was 1 partial responder and 3 of 7 patients had significant decreases in their PSA levels and pain scores.
Immune evaluations of peripheral blood mononuclear cells in 2 patients before and after immunotherapy showed increases in IFN-γ EliSpot responses and Th1 serum cytokines.
Conclusions.
These results provide a strong rationale for developing phase II trials to determine whether aATC are effective for treating CRPC.
American Psychological Association (APA)
Vaishampayan, Ulka& Thakur, Archana& Rathore, Ritesh& Kouttab, Nicola& Lum, Lawrence G.. 2015. Phase I Study of Anti-CD3 x Anti-Her2 Bispecific Antibody in Metastatic Castrate Resistant Prostate Cancer Patients. Prostate Cancer،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075836
Modern Language Association (MLA)
Vaishampayan, Ulka…[et al.]. Phase I Study of Anti-CD3 x Anti-Her2 Bispecific Antibody in Metastatic Castrate Resistant Prostate Cancer Patients. Prostate Cancer No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075836
American Medical Association (AMA)
Vaishampayan, Ulka& Thakur, Archana& Rathore, Ritesh& Kouttab, Nicola& Lum, Lawrence G.. Phase I Study of Anti-CD3 x Anti-Her2 Bispecific Antibody in Metastatic Castrate Resistant Prostate Cancer Patients. Prostate Cancer. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075836