Mitochondrial Dysfunction and α -Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First?
Joint Authors
Zaltieri, Michela
Longhena, Francesca
Pizzi, Marina
Missale, Cristina
Spano, PierFranco
Bellucci, Arianna
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder.
Its characteristic neuropathological features encompass the loss of dopaminergic neurons of the nigrostriatal system and the presence of Lewy bodies and Lewy neurites.
These are intraneuronal and intraneuritic proteinaceous insoluble aggregates whose main constituent is the synaptic protein α-synuclein.
Compelling lines of evidence indicate that mitochondrial dysfunction and α-synuclein synaptic deposition may play a primary role in the onset of this disorder.
However, it is not yet clear which of these events may come first in the sequel of processes leading to neurodegeneration.
Here, we reviewed data supporting either that α-synuclein synaptic deposition precedes and indirectly triggers mitochondrial damage or that mitochondrial deficits lead to neuronal dysfunction and α-synuclein synaptic accumulation.
The present overview shows that it is still difficult to establish the exact temporal sequence and contribution of these events to PD.
American Psychological Association (APA)
Zaltieri, Michela& Longhena, Francesca& Pizzi, Marina& Missale, Cristina& Spano, PierFranco& Bellucci, Arianna. 2015. Mitochondrial Dysfunction and α -Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First?. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075844
Modern Language Association (MLA)
Zaltieri, Michela…[et al.]. Mitochondrial Dysfunction and α -Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First?. Parkinson’s Disease No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075844
American Medical Association (AMA)
Zaltieri, Michela& Longhena, Francesca& Pizzi, Marina& Missale, Cristina& Spano, PierFranco& Bellucci, Arianna. Mitochondrial Dysfunction and α -Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First?. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075844