Transdermal Rotigotine Improves Sleep Fragmentation in Parkinson’s Disease: Results of the Multicenter, Prospective SLEEP-FRAM Study
Joint Authors
Piñol, Gerard
Cardozo, Adriana
Sanz, Pilar
Puente, Víctor
Otermín, Pilar
Legarda, Inés
Delgado, Tania
Serrano, Carmen
Balaguer, Ernest
Aguirregomozcorta, María
Álvarez, Ramiro
Pagonabarraga, Javier
Kulisevsky, Jaime
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Sleep disturbances occur frequently in patients with Parkinson’s disease (PD).
The aim of this study was to investigate the effects of rotigotine on sleep fluctuations in a sample of PD patients with self-reported complaints of nocturnal awakenings.
This prospective, open-label, observational, and multicenter study enrolled consecutive outpatients with PD and administered rotigotine (mean dose 8.9 mg/day) for 3 months.
The primary endpoint was the change from baseline in sleep fragmentation, assessed using the sleep maintenance subscale score of the Parkinson’s Disease Sleep Scale (PDSS).
The newly designed Parkinson’s Disease Sleep Fragmentation Questionnaire (PD-SFQ) was used to measure other sleep parameters.
A total of 62 patients were enrolled (mean age 70.2 years; 66% male).
At 3 months, rotigotine significantly improved sleep fragmentation from baseline on the PDSS-2 sleep maintenance subscale (from 3.4 ± 0.9 to 1.9 ± 1.4 ; P < 0.0001 ).
Rotigotine also significantly improved nocturnal motor symptoms P < 0.0001 , restless legs-like symptoms P < 0.005 , and nocturia P = 0.004 .
Rotigotine significantly improved self-reported complaints of sleep fragmentation in PD patients and could be a useful treatment to improve this specific sleep problem in PD.
However, these results are based on a small and clinically heterogeneous sample so they must be taken cautiously.
American Psychological Association (APA)
Pagonabarraga, Javier& Piñol, Gerard& Cardozo, Adriana& Sanz, Pilar& Puente, Víctor& Otermín, Pilar…[et al.]. 2015. Transdermal Rotigotine Improves Sleep Fragmentation in Parkinson’s Disease: Results of the Multicenter, Prospective SLEEP-FRAM Study. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075847
Modern Language Association (MLA)
Pagonabarraga, Javier…[et al.]. Transdermal Rotigotine Improves Sleep Fragmentation in Parkinson’s Disease: Results of the Multicenter, Prospective SLEEP-FRAM Study. Parkinson’s Disease No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075847
American Medical Association (AMA)
Pagonabarraga, Javier& Piñol, Gerard& Cardozo, Adriana& Sanz, Pilar& Puente, Víctor& Otermín, Pilar…[et al.]. Transdermal Rotigotine Improves Sleep Fragmentation in Parkinson’s Disease: Results of the Multicenter, Prospective SLEEP-FRAM Study. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075847