Orbitofrontal 18F-DOPA Uptake and Movement Preparation in Parkinson’s Disease
Joint Authors
Piccardo, Arnoldo
Trompetto, Carlo
Mori, Laura
Abbruzzese, Giovanni
Morbelli, Silvia
Girtler, Nicola
Castaldi, Antonio
Ghilardi, Maria Felice
Nobili, Flavio Mariano
Picco, Agnese
Marinelli, Lucio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In Parkinson’s disease (PD) degeneration of mesocortical dopaminergic projections may determine cognitive and behavioral symptoms.
Choice reaction time task is related to attention, working memory, and goal-directed behavior.
Such paradigm involves frontal cortical circuits receiving mesocortical dopamine which are affected early in PD.
The aim of this study is to characterize the role of dopamine on the cognitive processes that precede movement in a reaction time paradigm in PD.
We enrolled 16 newly diagnosed and untreated patients with PD without cognitive impairment or depression and 10 control subjects with essential tremor.
They performed multiple-choice reaction time task with the right upper limb and brain 18F-DOPA PET/CT scan.
A significant inverse correlation was highlighted between average reaction time and 18F-DOPA uptake in the left lateral orbitofrontal cortex.
No correlations were found between reaction time and PD disease severity or between reaction time and 18F-DOPA uptake in controls.
Our study shows that in PD, but not in controls, reaction time is inversely related to the levels of dopamine in the left lateral orbitofrontal cortex.
This novel finding underlines the role of dopamine in the lateral orbitofrontal cortex in the early stages of PD, supporting a relation between the compensatory cortical dopamine and movement preparation.
American Psychological Association (APA)
Marinelli, Lucio& Piccardo, Arnoldo& Mori, Laura& Morbelli, Silvia& Girtler, Nicola& Castaldi, Antonio…[et al.]. 2015. Orbitofrontal 18F-DOPA Uptake and Movement Preparation in Parkinson’s Disease. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075850
Modern Language Association (MLA)
Marinelli, Lucio…[et al.]. Orbitofrontal 18F-DOPA Uptake and Movement Preparation in Parkinson’s Disease. Parkinson’s Disease No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075850
American Medical Association (AMA)
Marinelli, Lucio& Piccardo, Arnoldo& Mori, Laura& Morbelli, Silvia& Girtler, Nicola& Castaldi, Antonio…[et al.]. Orbitofrontal 18F-DOPA Uptake and Movement Preparation in Parkinson’s Disease. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075850
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075850