MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson’s Disease
Joint Authors
Schlesinger, Ilana
Eran, Ayelet
Sinai, Alon
Erikh, Ilana
Nassar, Maria
Goldsher, Dorith
Zaaroor, Menashe
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-02
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Thalamotomy is effective in alleviating tremor in Parkinson’s disease (PD).
Methods.
Seven PD patients, mean age 59.4 ± 9.8 years (range, 46–74) with a mean disease duration of 5.4 ± 2.8 years (range, 2–10) suffering from severe refractory tremor, underwent ventral intermediate nucleus thalamotomy using MRI guided focused ultrasound (MRgFUS), an innovative technology that enables noninvasive surgery.
Results.
Tremor stopped in the contralateral upper extremity in all patients immediately following treatment.
Total UPDRS decreased from 37.4 ± 12.2 to 18.8 ± 11.1 (p=0.007) and PDQ-39 decreased from 42.3 ± 16.4 to 21.6 ± 10.8 (p=0.008) following MRgFUS.
These effects were sustained (mean follow-up 7.3 months).
Adverse events during MRgFUS included headache (n=3), dizziness (n=2), vertigo (n=4), and lip paresthesia (n=1) and following MRgFUS were hypogeusia (n=1), unsteady feeling when walking (n=1, resolved), and disturbance when walking tandem (n=1, resolved).
Conclusions.
Thalamotomy using MRgFUS is safe and effective in PD patients.
Large randomized studies are needed to assess prolonged efficacy and safety.
American Psychological Association (APA)
Schlesinger, Ilana& Eran, Ayelet& Sinai, Alon& Erikh, Ilana& Nassar, Maria& Goldsher, Dorith…[et al.]. 2015. MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson’s Disease. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1075855
Modern Language Association (MLA)
Schlesinger, Ilana…[et al.]. MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson’s Disease. Parkinson’s Disease No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1075855
American Medical Association (AMA)
Schlesinger, Ilana& Eran, Ayelet& Sinai, Alon& Erikh, Ilana& Nassar, Maria& Goldsher, Dorith…[et al.]. MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson’s Disease. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1075855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075855