Potential Biomarkers of the Earliest Clinical Stages of Parkinson’s Disease
Joint Authors
Slominsky, Petr A.
Karabanov, Aleksey V.
Illarioshkin, Sergey N.
Shadrina, Maria I.
Filatova, Elena V.
Alieva, Anelya Kh.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Parkinson’s disease (PD) is a widespread neurodegenerative disorder.
Despite the intensive studies of this pathology, in general, the picture of the etiopathogenesis has still not been clarified fully.
To understand better the mechanisms underlying the pathogenesis of PD, we analyzed the expression of 10 genes in the peripheral blood of treated and untreated patients with PD.
35 untreated patients with PD and 12 treated patients with Parkinson’s disease (Hoehn and Yahr scores 1-2) were studied.
An analysis of the mRNA levels of ATP13A2, PARK2, PARK7, PINK1, LRRK2, SNCA, ALDH1A1, PDHB, PPARGC1A, and ZNF746 genes in the peripheral blood of patients was carried out using reverse transcription followed by real-time PCR.
A statistically significant and specific increase by more than 1.5-fold in the expression of the ATP13A2, PARK7, and ZNF746 genes was observed in patients with PD.
Based on these results, it can be suggested that the upregulation of the mRNA levels of ATP13A2, PARK7, and ZNF746 in untreated patients in the earliest clinical stages can also be observed in the preclinical stages of PD, and that these genes can be considered as potential biomarkers of the preclinical stage of PD.
American Psychological Association (APA)
Alieva, Anelya Kh.& Filatova, Elena V.& Karabanov, Aleksey V.& Illarioshkin, Sergey N.& Slominsky, Petr A.& Shadrina, Maria I.. 2015. Potential Biomarkers of the Earliest Clinical Stages of Parkinson’s Disease. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075861
Modern Language Association (MLA)
Alieva, Anelya Kh.…[et al.]. Potential Biomarkers of the Earliest Clinical Stages of Parkinson’s Disease. Parkinson’s Disease No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1075861
American Medical Association (AMA)
Alieva, Anelya Kh.& Filatova, Elena V.& Karabanov, Aleksey V.& Illarioshkin, Sergey N.& Slominsky, Petr A.& Shadrina, Maria I.. Potential Biomarkers of the Earliest Clinical Stages of Parkinson’s Disease. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075861