Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study
Joint Authors
Dong, YanHong
Koay, Way Inn
Yeo, Leonard Leong Litt
Chen, Christopher Li-Hsian
Xu, Jing
Seet, Raymond Chee Seong
Lim, Erle Chuen Hian
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
This study sought to establish the discriminant validity of a rapid cognitive screen, that is, the National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute protocol, and compare its discriminant validity to the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE) in detecting cognitive impairment (CI) in PD patients.
Methods.
One hundred and one PD patients were recruited from a movement disorders clinic in Singapore and they received the NINDS-CSN 5-minute protocol, MoCA, and MMSE.
No cognitive impairment (NCI) was defined as Clinical Dementia Rating (CDR) = 0 and CI was defined as CDR ≥ 0.5.
Results.
Area under the receiver operating characteristic curve of NINDS-CSN 5-minute protocol was statistically equivalent to MoCA and larger than MMSE (0.86 versus 0.90, P = 0.07 ; 0.86 versus 0.76, P = 0.03 ).
The sensitivity of NINDS-CSN 5-minute protocol (<9) was statistically equivalent to MoCA (<22) (0.77 versus 0.85, P = 0.13 ) and superior to MMSE (<24) (0.77 versus 0.52, P < 0.01 ) in detecting CI, while the specificity of NINDS-CSN 5-minute protocol (<9) was statistically equivalent to MoCA (<22) and MMSE (<24) (0.78 versus 0.88, P = 0.34 ).
Conclusion.
The NINDS-CSN 5-minute protocol is time expeditious while remaining statistically equivalent to MoCA and superior to MMSE and therefore is suitable for rapid cognitive screening of CI in PD patients.
American Psychological Association (APA)
Dong, YanHong& Koay, Way Inn& Yeo, Leonard Leong Litt & Chen, Christopher Li-Hsian& Xu, Jing& Seet, Raymond Chee Seong…[et al.]. 2015. Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075865
Modern Language Association (MLA)
Dong, YanHong…[et al.]. Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study. Parkinson’s Disease No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1075865
American Medical Association (AMA)
Dong, YanHong& Koay, Way Inn& Yeo, Leonard Leong Litt & Chen, Christopher Li-Hsian& Xu, Jing& Seet, Raymond Chee Seong…[et al.]. Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075865