Dopaminergic Modulation of Medial Prefrontal Cortex Deactivation in Parkinson Depression
Joint Authors
Andersen, Anders H.
Smith, Charles D.
Slevin, John T.
Martin, Catherine A.
Schmitt, Frederick A.
Blonder, Lee X.
Kryscio, Richard J.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Parkinson’s disease (PD) is associated with emotional abnormalities.
Dopaminergic medications ameliorate Parkinsonian motor symptoms, but less is known regarding the impact of dopaminergic agents on affective processing, particularly in depressed PD (dPD) patients.
The aim of this study was to examine the effects of dopaminergic pharmacotherapy on brain activation to emotional stimuli in depressed versus nondepressed Parkinson disease (ndPD) patients.
Participants included 18 ndPD patients (11 men, 7 women) and 10 dPD patients (7 men, 3 women).
Patients viewed photographs of emotional faces during functional MRI.
Scans were performed while the patient was taking anti-Parkinson medication and the day after medication had been temporarily discontinued.
Results indicate that dopaminergic medications have opposite effects in the prefrontal cortex depending upon depression status.
DPD patients show greater deactivation in the ventromedial prefrontal cortex (VMPFC) on dopaminergic medications than off, while ndPD patients show greater deactivation in this region off drugs.
The VMPFC is in the default-mode network (DMN).
DMN activity is negatively correlated with activity in brain systems used for external visual attention.
Thus dopaminergic medications may promote increased attention to external visual stimuli among dPD patients but impede normal suppression of DMN activity during external stimulation among ndPD patients.
American Psychological Association (APA)
Andersen, Anders H.& Smith, Charles D.& Slevin, John T.& Kryscio, Richard J.& Martin, Catherine A.& Schmitt, Frederick A.…[et al.]. 2015. Dopaminergic Modulation of Medial Prefrontal Cortex Deactivation in Parkinson Depression. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075887
Modern Language Association (MLA)
Andersen, Anders H.…[et al.]. Dopaminergic Modulation of Medial Prefrontal Cortex Deactivation in Parkinson Depression. Parkinson’s Disease No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075887
American Medical Association (AMA)
Andersen, Anders H.& Smith, Charles D.& Slevin, John T.& Kryscio, Richard J.& Martin, Catherine A.& Schmitt, Frederick A.…[et al.]. Dopaminergic Modulation of Medial Prefrontal Cortex Deactivation in Parkinson Depression. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075887