Abnormal Cerebrovascular Reactivity in Patients with Parkinson’s Disease
Joint Authors
Schafranski, Marcelo Derbli
Camargo, Carlos Henrique Ferreira
Martins, Eduardo Antunes
Lange, Marcos Christiano
Hoffmann, Henrique Alvaro
Luciano, Jissa Jeanete
Young Blood, Marcelo Rezende
Ferro, Marcelo Machado
Miyoshi, Edmar
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Orthostatic hypotension (OH) is an important nonmotor manifestation of Parkinson’s disease (PD).
Changes in cerebrovascular reactivity may contribute to this manifestation and can be monitored using transcranial Doppler.
Objective.
To identify possible changes in cerebrovascular reactivity in patients with OH.
Methods.
Twenty-two individuals were selected and divided into three groups: with and without OH and controls.
Transcranial Doppler was used to assess basal mean blood flow velocity, postapnea mean blood flow velocity, percentage increase in mean blood flow velocity, and cerebrovascular reactivity as measured by the breath-holding index.
Results.
PD patients had lower values of basal velocity (p=0.019), postapnea velocity (p=0.0015), percentage increase in velocity (p=0.039), and breath-holding index (p=0.04) than the controls.
Patients with OH had higher values of basal velocity (p=0.09) and postapnea velocity (p=0.19) but lower values of percentage increase in velocity (p=0.22) and breath-holding index (p=0.32) than patients without OH.
Conclusions.
PD patients present with abnormalities in a compensatory mechanism that regulates cerebral blood flow.
OH could be an indicator of these abnormalities.
American Psychological Association (APA)
Camargo, Carlos Henrique Ferreira& Martins, Eduardo Antunes& Lange, Marcos Christiano& Hoffmann, Henrique Alvaro& Luciano, Jissa Jeanete& Young Blood, Marcelo Rezende…[et al.]. 2015. Abnormal Cerebrovascular Reactivity in Patients with Parkinson’s Disease. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075889
Modern Language Association (MLA)
Camargo, Carlos Henrique Ferreira…[et al.]. Abnormal Cerebrovascular Reactivity in Patients with Parkinson’s Disease. Parkinson’s Disease No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1075889
American Medical Association (AMA)
Camargo, Carlos Henrique Ferreira& Martins, Eduardo Antunes& Lange, Marcos Christiano& Hoffmann, Henrique Alvaro& Luciano, Jissa Jeanete& Young Blood, Marcelo Rezende…[et al.]. Abnormal Cerebrovascular Reactivity in Patients with Parkinson’s Disease. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075889