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Myocardial 123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s Disease
Joint Authors
Kuwabara, Satoshi
Katagiri, Akira
Asahina, Masato
Araki, Nobuyuki
Poudel, Anupama
Fujinuma, Yoshikatsu
Yamanaka, Yoshitaka
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Patients with Parkinson’s disease (PD) showed reduced myocardial 123I-MIBG uptake, which may affect autonomic regulation.
We investigated correlation between MIBC accumulation and cardiovascular autonomic function in PD.
Methods.
We performed myocardial MIBG scintigraphy, heart rate variability (HRV) analysis, and the head-up tilt test (HUT) in 50 PD patients (66.4±7.8 years; duration 5.5±5.9 years).
Autonomic function tests were also performed in 50 healthy controls (66.5±8.9 years).
As HRV parameters, a high-frequency power (HF, 0.15–0.4 Hz), a low-frequency power (LF, 0.04–0.15 Hz), and LF/HF ratio were used.
Results.
Our PD patients had a significant reduction in LF and HF compared with the controls (P=0.005 and P=0.01).
In HUT, systolic and diastolic blood pressure falls in the PD group were significantly greater than those in the controls (P=0.02 and P=0.02).
The washout rate of MIBG was negatively correlated with blood pressure changes during HUT.
Conclusion.
Our PD patients showed reduced HRV, blood pressure dysregulation, and reduced MIBG accumulation, which was correlated with blood pressure dysregulation.
Orthostatic hypotension in PD may be mainly caused by sympathetic postganglionic degeneration.
American Psychological Association (APA)
Katagiri, Akira& Asahina, Masato& Araki, Nobuyuki& Poudel, Anupama& Fujinuma, Yoshikatsu& Yamanaka, Yoshitaka…[et al.]. 2015. Myocardial 123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s Disease. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075911
Modern Language Association (MLA)
Katagiri, Akira…[et al.]. Myocardial 123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s Disease. Parkinson’s Disease No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1075911
American Medical Association (AMA)
Katagiri, Akira& Asahina, Masato& Araki, Nobuyuki& Poudel, Anupama& Fujinuma, Yoshikatsu& Yamanaka, Yoshitaka…[et al.]. Myocardial 123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s Disease. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075911