Association Analysis of COQ2 Variant in Dementia and Essential Tremor
Joint Authors
Chao, Yinxia
Zhao, Yi
Au, Wing Lok
Tan, Louis Chew Seng
Ng, Ebonne Yu Lin
Li, Huihua
Nagaendran, Kandiah
Yih, Yuen
Chong, Mei Sian
Prakash, Kumar M.
Zhou, Zhi Dong
Tio, Murni
Pavanni, Ratnagopal
Tan, Eng King
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objective.
COQ2 mutations have been reported in Japanese multiple system atrophy (MSA) patients.
We examined the role of COQ2 in patients with dementia and essential tremor (ET), two common neurodegenerative conditions.
Materials & Methods.
A total of 2064 subjects, including 560 patients with dementia, 466 patients with ET, and 1038 healthy controls, were included.
Genotyping for the COQ2 V393A (T>C) was carried out.
Odds ratio (OR) adjusted by age and gender, together with 95% confidence interval (CI), was reported by means of logistic regression.
Results.
The frequency of the polymorphic variant V393A heterozygous (T/C) was 2.7% in dementia, 1.1% in ET, and 2.5% in controls (OR = 0.70, 95% confidence interval is 0.29–1.72 for dementia, and OR = 0.47, 95% confidence interval is 0.17–1.31, p=0.1217 for ET).
There was no significant association between V393A variant with dementia and ET.
Conclusion.
There was no significant association between V393A variant with dementia and ET.
COQ2 gene is unlikely to play a significant role in patients with dementia or ET in our population.
American Psychological Association (APA)
Chao, Yinxia& Ng, Ebonne Yu Lin& Li, Huihua& Nagaendran, Kandiah& Yih, Yuen& Chong, Mei Sian…[et al.]. 2015. Association Analysis of COQ2 Variant in Dementia and Essential Tremor. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1075924
Modern Language Association (MLA)
Chao, Yinxia…[et al.]. Association Analysis of COQ2 Variant in Dementia and Essential Tremor. Parkinson’s Disease No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1075924
American Medical Association (AMA)
Chao, Yinxia& Ng, Ebonne Yu Lin& Li, Huihua& Nagaendran, Kandiah& Yih, Yuen& Chong, Mei Sian…[et al.]. Association Analysis of COQ2 Variant in Dementia and Essential Tremor. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1075924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075924