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The Role of PPAR Gamma in Systemic Sclerosis
Joint Authors
Pitta, Ivan da Rocha
Pereira, Michelly Cristiny
Marques, Claudia Diniz Lopes
Rego, Moacyr Jesus Barreto de Melo
Duarte, Angela Luzia Branco Pinto
da Rocha Junior, Laurindo Ferreira
Pitta, Maira Galdino da Rocha
Dantas, Andréa Tavares
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Fibrosis is recognized as an important feature of many chronic diseases, such as systemic sclerosis (SSc), an autoimmune disease of unknown etiology, characterized by immune dysregulation and vascular injury, followed by progressive fibrosis affecting the skin and multiple internal organs.
SSc has a poor prognosis because no therapy has been shown to reverse or arrest the progression of fibrosis, representing a major unmet medical need.
Recently, antifibrotic effects of PPARγ ligands have been studied in vitro and in vivo and some theories have emerged leading to new insights.
Aberrant PPARγ function seems to be implicated in pathological fibrosis in the skin and lungs.
This antifibrotic effect is mainly related to the inhibition of TGF-β/Smad signal transduction but other pathways can be involved.
This review focused on recent studies that identified PPARγ as an important novel pathway with critical roles in regulating connective tissue homeostasis, with emphasis on skin and lung fibrosis and its role on systemic sclerosis.
American Psychological Association (APA)
Dantas, Andréa Tavares& Pereira, Michelly Cristiny& Rego, Moacyr Jesus Barreto de Melo& da Rocha Junior, Laurindo Ferreira& Pitta, Ivan da Rocha& Marques, Claudia Diniz Lopes…[et al.]. 2015. The Role of PPAR Gamma in Systemic Sclerosis. PPAR Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075952
Modern Language Association (MLA)
Dantas, Andréa Tavares…[et al.]. The Role of PPAR Gamma in Systemic Sclerosis. PPAR Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075952
American Medical Association (AMA)
Dantas, Andréa Tavares& Pereira, Michelly Cristiny& Rego, Moacyr Jesus Barreto de Melo& da Rocha Junior, Laurindo Ferreira& Pitta, Ivan da Rocha& Marques, Claudia Diniz Lopes…[et al.]. The Role of PPAR Gamma in Systemic Sclerosis. PPAR Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075952