Peroxisome Proliferator-Activated Receptor-γ in Thyroid Autoimmunity
Joint Authors
Fallahi, Poupak
Antonelli, Alessandro
Vita, Roberto
Benvenga, Salvatore
Ferrari, Silvia Martina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptor- (PPAR-) γ expression has been shown in thyroid tissue from patients with thyroiditis or Graves’ disease and furthermore in the orbital tissue of patients with Graves’ ophthalmopathy (GO), such as in extraocular muscle cells.
An increasing body of evidence shows the importance of the (C-X-C motif) receptor 3 (CXCR3) and cognate chemokines (C-X-C motif) ligand (CXCL)9, CXCL10, and CXCL11, in the T helper 1 immune response and in inflammatory diseases such as thyroid autoimmune disorders.
PPAR-γ agonists show a strong inhibitory effect on the expression and release of CXCR3 chemokines, in vitro, in various kinds of cells, such as thyrocytes, and in orbital fibroblasts, preadipocytes, and myoblasts from patients with GO.
Recently, it has been demonstrated that rosiglitazone is involved in a higher risk of heart failure, stroke, and all-cause mortality in old patients.
On the contrary, pioglitazone has not shown these effects until now; this favors pioglitazone for a possible use in patients with thyroid autoimmunity.
However, further studies are ongoing to explore the use of new PPAR-γ agonists in the treatment of thyroid autoimmune disorders.
American Psychological Association (APA)
Ferrari, Silvia Martina& Fallahi, Poupak& Vita, Roberto& Antonelli, Alessandro& Benvenga, Salvatore. 2015. Peroxisome Proliferator-Activated Receptor-γ in Thyroid Autoimmunity. PPAR Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075954
Modern Language Association (MLA)
Ferrari, Silvia Martina…[et al.]. Peroxisome Proliferator-Activated Receptor-γ in Thyroid Autoimmunity. PPAR Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075954
American Medical Association (AMA)
Ferrari, Silvia Martina& Fallahi, Poupak& Vita, Roberto& Antonelli, Alessandro& Benvenga, Salvatore. Peroxisome Proliferator-Activated Receptor-γ in Thyroid Autoimmunity. PPAR Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075954
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075954