PPARγ and the Innate Immune System Mediate the Resolution of Inflammation
Joint Authors
Phipps, Richard P.
Sime, Patricia J.
Croasdell, Amanda
Duffney, Parker F.
Kim, Nina
Lacy, Shannon H.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-02
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
The resolution of inflammation is an active and dynamic process, mediated in large part by the innate immune system.
Resolution represents not only an increase in anti-inflammatory actions, but also a paradigm shift in immune cell function to restore homeostasis.
PPARγ, a ligand activated transcription factor, has long been studied for its anti-inflammatory actions, but an emerging body of literature is investigating the role of PPARγ and its ligands (including thiazolidinediones, prostaglandins, and oleanolic acids) in all phases of resolution.
PPARγ can shift production from pro- to anti-inflammatory mediators by neutrophils, platelets, and macrophages.
PPARγ and its ligands further modulate platelet and neutrophil function, decreasing trafficking, promoting neutrophil apoptosis, and preventing platelet-leukocyte interactions.
PPARγ alters macrophage trafficking, increases efferocytosis and phagocytosis, and promotes alternative M2 macrophage activation.
There are also roles for this receptor in the adaptive immune response, particularly regarding B cells.
These effects contribute towards the attenuation of multiple disease states, including COPD, colitis, Alzheimer’s disease, and obesity in animal models.
Finally, novel specialized proresolving mediators—eicosanoids with critical roles in resolution—may act through PPARγ modulation to promote resolution, providing another exciting area of therapeutic potential for this receptor.
American Psychological Association (APA)
Croasdell, Amanda& Duffney, Parker F.& Kim, Nina& Lacy, Shannon H.& Sime, Patricia J.& Phipps, Richard P.. 2015. PPARγ and the Innate Immune System Mediate the Resolution of Inflammation. PPAR Research،Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1075963
Modern Language Association (MLA)
Croasdell, Amanda…[et al.]. PPARγ and the Innate Immune System Mediate the Resolution of Inflammation. PPAR Research No. 2015 (2015), pp.1-20.
https://search.emarefa.net/detail/BIM-1075963
American Medical Association (AMA)
Croasdell, Amanda& Duffney, Parker F.& Kim, Nina& Lacy, Shannon H.& Sime, Patricia J.& Phipps, Richard P.. PPARγ and the Innate Immune System Mediate the Resolution of Inflammation. PPAR Research. 2015. Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1075963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075963