Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment
Joint Authors
Moran, Elizabeth P.
Ma, Jian-Xing
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Peroxisome-proliferator activated receptor-alpha (PPARα) is a broadly expressed nuclear hormone receptor and is a transcription factor for diverse target genes possessing a PPAR response element (PPRE) in the promoter region.
The PPRE is highly conserved, and PPARs thus regulate transcription of an extensive array of target genes involved in energy metabolism, vascular function, oxidative stress, inflammation, and many other biological processes.
PPARα has potent protective effects against neuronal cell death and microvascular impairment, which have been attributed in part to its antioxidant and anti-inflammatory properties.
Here we discuss PPARα’s effects in neurodegenerative and microvascular diseases and also recent clinical findings that identified therapeutic effects of a PPARα agonist in diabetic microvascular complications.
American Psychological Association (APA)
Moran, Elizabeth P.& Ma, Jian-Xing. 2015. Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment. PPAR Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075964
Modern Language Association (MLA)
Moran, Elizabeth P.& Ma, Jian-Xing. Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment. PPAR Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075964
American Medical Association (AMA)
Moran, Elizabeth P.& Ma, Jian-Xing. Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment. PPAR Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075964