PPARs: Protectors or Opponents of Myocardial Function?
Joint Authors
Pol, Christine J.
Lieu, Melissa
Drosatos, Konstantinos
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-02
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Over 5 million people in the United States suffer from the complications of heart failure (HF), which is a rapidly expanding health complication.
Disorders that contribute to HF include ischemic cardiac disease, cardiomyopathies, and hypertension.
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor family.
There are three PPAR isoforms: PPARα, PPARγ, and PPARδ.
They can be activated by endogenous ligands, such as fatty acids, as well as by pharmacologic agents.
Activators of PPARs are used for treating several metabolic complications, such as diabetes and hyperlipidemia that are directly or indirectly associated with HF.
However, some of these drugs have adverse effects that compromise cardiac function.
This review article aims to summarize the current basic and clinical research findings of the beneficial or detrimental effects of PPAR biology on myocardial function.
American Psychological Association (APA)
Pol, Christine J.& Lieu, Melissa& Drosatos, Konstantinos. 2015. PPARs: Protectors or Opponents of Myocardial Function?. PPAR Research،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1075970
Modern Language Association (MLA)
Pol, Christine J.…[et al.]. PPARs: Protectors or Opponents of Myocardial Function?. PPAR Research No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1075970
American Medical Association (AMA)
Pol, Christine J.& Lieu, Melissa& Drosatos, Konstantinos. PPARs: Protectors or Opponents of Myocardial Function?. PPAR Research. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1075970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075970