Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke

Joint Authors

Butler, Andrew J.
Kallos, Justiss
Housley, Stephen N.
LaPlaca, Michelle C.
Traynelis, Stephen F.
Wolf, Steven L.

Source

Rehabilitation Research and Practice

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-10-26

Country of Publication

Egypt

No. of Pages

14

Main Subjects

Medicine

Abstract EN

Stroke is a leading cause of death and disability in the USA.

Up to 60% of patients do not fully recover despite intensive physical therapy treatment.

N-Methyl-D-aspartate receptors (NMDA-R) have been shown to play a role in synaptic plasticity when activated.

D-Cycloserine promotes NMDA receptor function by binding to receptors with unoccupied glycine sites.

These receptors are involved in learning and memory.

We hypothesized that D-cycloserine, when combined with robotic-assisted physiotherapy (RAP), would result in greater gains compared with placebo + RAP in stroke survivors.

Participants ( n = 14 ) were randomized to D-cycloserine plus RAP or placebo plus RAP.

Functional, cognitive, and quality-of-life measures were used to assess recovery.

There was significant improvement in grip strength of the affected hand within both groups from baseline to 3 weeks (95% confidence interval for mean change, 3.95 ± 2.96 to 4.90 ± 3.56 N for D-cycloserine and 5.72 ± 3.98 to 8.44 ± 4.90 N for control).

SIS mood domain showed improvement for both groups (95% confidence interval for mean change, 72.6 ± 16.3 to 82.9 ± 10.9 for D-cycloserine and 82.9 ± 13.5 to 90.3 ± 9.9 for control).

This preliminary study does not provide evidence that D-cycloserine can provide greater gains in learning compared with placebo for stroke survivors.

American Psychological Association (APA)

Butler, Andrew J.& Kallos, Justiss& Housley, Stephen N.& LaPlaca, Michelle C.& Traynelis, Stephen F.& Wolf, Steven L.. 2015. Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke. Rehabilitation Research and Practice،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076015

Modern Language Association (MLA)

Butler, Andrew J.…[et al.]. Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke. Rehabilitation Research and Practice No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1076015

American Medical Association (AMA)

Butler, Andrew J.& Kallos, Justiss& Housley, Stephen N.& LaPlaca, Michelle C.& Traynelis, Stephen F.& Wolf, Steven L.. Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke. Rehabilitation Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076015

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1076015