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Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke
Joint Authors
Butler, Andrew J.
Kallos, Justiss
Housley, Stephen N.
LaPlaca, Michelle C.
Traynelis, Stephen F.
Wolf, Steven L.
Source
Rehabilitation Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Stroke is a leading cause of death and disability in the USA.
Up to 60% of patients do not fully recover despite intensive physical therapy treatment.
N-Methyl-D-aspartate receptors (NMDA-R) have been shown to play a role in synaptic plasticity when activated.
D-Cycloserine promotes NMDA receptor function by binding to receptors with unoccupied glycine sites.
These receptors are involved in learning and memory.
We hypothesized that D-cycloserine, when combined with robotic-assisted physiotherapy (RAP), would result in greater gains compared with placebo + RAP in stroke survivors.
Participants ( n = 14 ) were randomized to D-cycloserine plus RAP or placebo plus RAP.
Functional, cognitive, and quality-of-life measures were used to assess recovery.
There was significant improvement in grip strength of the affected hand within both groups from baseline to 3 weeks (95% confidence interval for mean change, 3.95 ± 2.96 to 4.90 ± 3.56 N for D-cycloserine and 5.72 ± 3.98 to 8.44 ± 4.90 N for control).
SIS mood domain showed improvement for both groups (95% confidence interval for mean change, 72.6 ± 16.3 to 82.9 ± 10.9 for D-cycloserine and 82.9 ± 13.5 to 90.3 ± 9.9 for control).
This preliminary study does not provide evidence that D-cycloserine can provide greater gains in learning compared with placebo for stroke survivors.
American Psychological Association (APA)
Butler, Andrew J.& Kallos, Justiss& Housley, Stephen N.& LaPlaca, Michelle C.& Traynelis, Stephen F.& Wolf, Steven L.. 2015. Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke. Rehabilitation Research and Practice،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076015
Modern Language Association (MLA)
Butler, Andrew J.…[et al.]. Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke. Rehabilitation Research and Practice No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1076015
American Medical Association (AMA)
Butler, Andrew J.& Kallos, Justiss& Housley, Stephen N.& LaPlaca, Michelle C.& Traynelis, Stephen F.& Wolf, Steven L.. Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke. Rehabilitation Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076015