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Rhabdomyosarcoma: Advances in Molecular and Cellular Biology
Joint Authors
Duan, Zhenfeng
Hornicek, Francis J.
Sun, Xin
Guo, Wei
Shen, Jacson K.
Mankin, Henry J.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-01
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence.
The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually genetically heterogeneous.
The prognosis of RMS has improved in the past several decades due to multidisciplinary care.
However, in recent years, the treatment of patients with metastatic or refractory RMS has reached a plateau.
Thus, to improve the survival rate of RMS patients and their overall well-being, further understanding of the molecular and cellular biology of RMS and identification of novel therapeutic targets are imperative.
In this review, we describe the most recent discoveries in the molecular and cellular biology of RMS, including alterations in oncogenic pathways, miRNA (miR), in vivo models, stem cells, and important signal transduction cascades implicated in the development and progression of RMS.
Furthermore, we discuss novel potential targeted therapies that may improve the current treatment of RMS.
American Psychological Association (APA)
Sun, Xin& Guo, Wei& Shen, Jacson K.& Mankin, Henry J.& Hornicek, Francis J.& Duan, Zhenfeng. 2015. Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. Complexity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076062
Modern Language Association (MLA)
Sun, Xin…[et al.]. Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. Complexity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1076062
American Medical Association (AMA)
Sun, Xin& Guo, Wei& Shen, Jacson K.& Mankin, Henry J.& Hornicek, Francis J.& Duan, Zhenfeng. Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. Complexity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076062