Potential Therapeutic Targets in Uterine Sarcomas
Joint Authors
Cuppens, Tine
Tuyaerts, Sandra
Amant, Frédéric
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Uterine sarcomas are rare tumors accounting for 3,4% of all uterine cancers.
Even after radical hysterectomy, most patients relapse or present with distant metastases.
The very limited clinical benefit of adjuvant cytotoxic treatments is reflected by high mortality rates, emphasizing the need for new treatment strategies.
This review summarizes rising potential targets in four distinct subtypes of uterine sarcomas: leiomyosarcoma, low-grade and high-grade endometrial stromal sarcoma, and undifferentiated uterine sarcoma.
Based on clinical reports, promising approaches for uterine leiomyosarcoma patients include inhibition of VEGF and mTOR signaling, preferably in combination with other targeted or cytotoxic compounds.
Currently, the only targeted therapy approved in leiomyosarcoma patients is pazopanib, a multitargeted inhibitor blocking VEGFR, PDGFR, FGFR, and c-KIT.
Additionally, preclinical evidence suggests effect of the inhibition of histone deacetylases, tyrosine kinase receptors, and the mitotic checkpoint protein aurora kinase A.
In low-grade endometrial stromal sarcomas, antihormonal therapies including aromatase inhibitors and progestins have proven activity.
Other potential targets are PDGFR, VEGFR, and histone deacetylases.
In high-grade ESS that carry the YWHAE/FAM22A/B fusion gene, the generated 14-3-3 oncoprotein is a putative target, next to c-KIT and the Wnt pathway.
The observation of heterogeneity within uterine sarcoma subtypes warrants a personalized treatment approach.
American Psychological Association (APA)
Cuppens, Tine& Tuyaerts, Sandra& Amant, Frédéric. 2015. Potential Therapeutic Targets in Uterine Sarcomas. Complexity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076064
Modern Language Association (MLA)
Cuppens, Tine…[et al.]. Potential Therapeutic Targets in Uterine Sarcomas. Complexity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1076064
American Medical Association (AMA)
Cuppens, Tine& Tuyaerts, Sandra& Amant, Frédéric. Potential Therapeutic Targets in Uterine Sarcomas. Complexity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076064