Improvement in Overall Survival from Extremity Soft Tissue Sarcoma over Twenty Years
Joint Authors
Jacobs, Andrew J.
Michels, Ryan
Stein, Joanna
Levin, Adam S.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Several patient demographic factors, including marital status, have been demonstrated to have prognostic significance for survival in extremity soft tissue sarcoma (ESTS).
A study population of 12,546 adult patients diagnosed with ESTS from 1991 to 2010 was identified from the SEER database, a large population-based registry, in order to determine whether overall survival had changed over this recent 20-year period.
The study population was divided into three groups by year of diagnosis: 1991–1996, 1997–2003, and 2004–2010.
We used the Kaplan-Meier method and Cox proportional hazards regression to assess survival differences between different demographic groups and prognostic clinical characteristics.
Over the course of time, the 5-year overall survival rates have increased from 28% in the earliest time period to 62% in the latest (P<0.0001).
On multivariate analysis, the mortality rate progressively declined from the 1991–1996 group (HR: 3.02, CI: 2.78–3.29) to the 1997–2003 group (HR: 2.21, CI: 2.06–2.37), with the 2004–2010 group having the best overall survival, despite increases in the proportion of patients with tumors greater than 5 cm in size (P<0.0001), and those presenting with metastasis (P<0.0001).
American Psychological Association (APA)
Jacobs, Andrew J.& Michels, Ryan& Stein, Joanna& Levin, Adam S.. 2015. Improvement in Overall Survival from Extremity Soft Tissue Sarcoma over Twenty Years. Complexity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076067
Modern Language Association (MLA)
Jacobs, Andrew J.…[et al.]. Improvement in Overall Survival from Extremity Soft Tissue Sarcoma over Twenty Years. Complexity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1076067
American Medical Association (AMA)
Jacobs, Andrew J.& Michels, Ryan& Stein, Joanna& Levin, Adam S.. Improvement in Overall Survival from Extremity Soft Tissue Sarcoma over Twenty Years. Complexity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076067