Prognostic Factors and Treatment Results of High-Grade Osteosarcoma in Norway: A Scope Beyond the “Classical” Patient
Joint Authors
Bruland, Øyvind S.
Berner, Kjetil
Hall, Kirsten Sundby
Monge, Odd R.
Weedon-Fekjær, Harald
Zaikova, Olga
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Purpose.
A retrospective study of prognostic factors and treatment outcome of osteosarcoma (OS) during modern chemotherapy era with focus on patients with primary metastatic disease, nonextremity localisation, or age >40 years (nonclassical OS).
Methods.
A nationwide cohort, comprising 424 high-grade Norwegian bone OS patients, was based on registry sources supplemented with clinical records from hospitals involved in sarcoma management between 1975 and 2009.
Results.
Only 48% were younger patients with tumour in the extremities and without metastasis at diagnosis (classical OS).
A considerable discrepancy in survival between classical and nonclassical OS was observed: 61% versus 26% 10-year sarcoma specific survival.
Twice as many of the former received both adequate surgery and chemotherapy compared to the latter.
This could only partly explain the differences in survival due to inherent chemoresistance in primary metastatic disease and a higher rate of local relapse among patients with axial tumours.
Metastasis at diagnosis, increased lactate dehydrogenase, age > 40 years, and tumour size above median value were all adverse prognostic factors for overall survival.
Conclusion.
We confirm a dramatic difference in outcome between classical and nonclassical high-grade OS patients, but treatment variables could only partly explain the dismal outcome of the latter.
American Psychological Association (APA)
Berner, Kjetil& Hall, Kirsten Sundby& Monge, Odd R.& Weedon-Fekjær, Harald& Zaikova, Olga& Bruland, Øyvind S.. 2015. Prognostic Factors and Treatment Results of High-Grade Osteosarcoma in Norway: A Scope Beyond the “Classical” Patient. Complexity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076077
Modern Language Association (MLA)
Berner, Kjetil…[et al.]. Prognostic Factors and Treatment Results of High-Grade Osteosarcoma in Norway: A Scope Beyond the “Classical” Patient. Complexity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1076077
American Medical Association (AMA)
Berner, Kjetil& Hall, Kirsten Sundby& Monge, Odd R.& Weedon-Fekjær, Harald& Zaikova, Olga& Bruland, Øyvind S.. Prognostic Factors and Treatment Results of High-Grade Osteosarcoma in Norway: A Scope Beyond the “Classical” Patient. Complexity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076077