Analysis of the Intratumoral Adaptive Immune Response in Well Differentiated and Dedifferentiated Retroperitoneal Liposarcoma
Joint Authors
Tseng, William W.
Malu, Shruti
Zhang, Minying
Chen, Jieqing
Sim, Geok Choo
Wei, Wei
Ingram, Davis
Somaiah, Neeta
Lev, Dina C.
Pollock, Raphael E.
Lizée, Gregory
Radvanyi, Laszlo
Hwu, Patrick
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Treatment options are limited in well differentiated (WD) and dedifferentiated (DD) retroperitoneal liposarcoma.
We sought to study the intratumoral adaptive immune response and explore the potential feasibility of immunotherapy in this disease.
Tumor-infiltrating lymphocytes (TILs) were isolated from fresh surgical specimens and analyzed by flow cytometry for surface marker expression.
Previously reported immune cell aggregates known as tertiary lymphoid structures (TLS) were further characterized by immunohistochemistry.
In all fresh tumors, TILs were found.
The majority of TILs were CD4 T cells; however cytotoxic CD8 T cells were also seen (average: 20% of CD3 T cells).
Among CD8 T cells, 65% expressed the immune checkpoint molecule PD-1.
Intratumoral TLS may be sites of antigen presentation as DC-LAMP positive, mature dendritic cells were found juxtaposed next to CD4 T cells.
Clinicopathologic correlation, however, demonstrated that presence of TLS was associated with worse recurrence-free survival in WD disease and worse overall survival in DD disease.
Our data suggest that an adaptive immune response is present in WD/DD retroperitoneal liposarcoma but may be hindered by TLS, among other possible microenvironmental factors; further investigation is needed.
Immunotherapy, including immune checkpoint blockade, should be evaluated as a treatment option in this disease.
American Psychological Association (APA)
Tseng, William W.& Malu, Shruti& Zhang, Minying& Chen, Jieqing& Sim, Geok Choo& Wei, Wei…[et al.]. 2015. Analysis of the Intratumoral Adaptive Immune Response in Well Differentiated and Dedifferentiated Retroperitoneal Liposarcoma. Complexity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076081
Modern Language Association (MLA)
Tseng, William W.…[et al.]. Analysis of the Intratumoral Adaptive Immune Response in Well Differentiated and Dedifferentiated Retroperitoneal Liposarcoma. Complexity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1076081
American Medical Association (AMA)
Tseng, William W.& Malu, Shruti& Zhang, Minying& Chen, Jieqing& Sim, Geok Choo& Wei, Wei…[et al.]. Analysis of the Intratumoral Adaptive Immune Response in Well Differentiated and Dedifferentiated Retroperitoneal Liposarcoma. Complexity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076081