Management Strategies in Advanced Uterine Leiomyosarcoma: Focus on Trabectedin
Joint Authors
Amant, Frédéric
Mustea, Alexander
Duffaud, Florence
Pautier, Patricia
Lo Russo, D.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The treatment of advanced uterine leiomyosarcomas (U-LMS) represents a considerable challenge.
Radiological diagnosis prior to hysterectomy is difficult, with the diagnosis frequently made postoperatively.
Whilst a total abdominal hysterectomy is the cornerstone of management of early disease, the role of routine adjuvant pelvic radiotherapy and adjuvant chemotherapy is less clear, since they may improve local tumor control in high risk patients but are not associated with an overall survival benefit.
For recurrent or disseminated U-LMS, cytotoxic chemotherapy remains the mainstay of treatment.
There have been few active chemotherapy drugs approved for advanced disease, although newer drugs such as trabectedin with its pleiotropic mechanism of actions represent an important addition to the standard front-line systemic therapy with doxorubicin and ifosfamide.
In this review, we outline the therapeutic potential and in particular the emerging evidence-based strategy of therapy with trabectedin in patients with advanced U-LMS.
American Psychological Association (APA)
Amant, Frédéric& Lo Russo, D.& Mustea, Alexander& Duffaud, Florence& Pautier, Patricia. 2015. Management Strategies in Advanced Uterine Leiomyosarcoma: Focus on Trabectedin. Complexity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076095
Modern Language Association (MLA)
Amant, Frédéric…[et al.]. Management Strategies in Advanced Uterine Leiomyosarcoma: Focus on Trabectedin. Complexity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1076095
American Medical Association (AMA)
Amant, Frédéric& Lo Russo, D.& Mustea, Alexander& Duffaud, Florence& Pautier, Patricia. Management Strategies in Advanced Uterine Leiomyosarcoma: Focus on Trabectedin. Complexity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076095