A Patient-Derived Xenograft Model of Parameningeal Embryonal Rhabdomyosarcoma for Preclinical Studies
Joint Authors
Hooper, Jody E.
Cantor, Emma L.
Ehlen, Macgregor S.
Banerjee, Avirup
Malempati, Suman
Woltjer, Randy L.
Gandour-Edwards, Regina
Goodwin, Neal C.
Yang, Yan
Kaur, Pali
Bult, Carol J.
Airhart, Susan D.
Keller, Charles
Stenzel, Peter
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Embryonal rhabdomyosarcoma (eRMS) is one of the most common soft tissue sarcomas in children and adolescents.
Parameningeal eRMS is a variant that is often more difficult to treat than eRMS occurring at other sites.
A 14-year-old female with persistent headaches and rapid weight loss was diagnosed with parameningeal eRMS.
She progressed and died despite chemotherapy with vincristine, actinomycin-D, and cyclophosphamide plus 50.4 Gy radiation therapy to the primary tumor site.
Tumor specimens were acquired by rapid autopsy and tumor tissue was transplanted into immunodeficient mice to create a patient-derived xenograft (PDX) animal model.
As autopsy specimens had an ALK R1181C mutation, PDX tumor bearing animals were treated with the pan-kinase inhibitor lestaurtinib but demonstrated no decrease in tumor growth, suggesting that single agent kinase inhibitor therapy may be insufficient in similar cases.
This unique parameningeal eRMS PDX model is publicly available for preclinical study.
American Psychological Association (APA)
Hooper, Jody E.& Cantor, Emma L.& Ehlen, Macgregor S.& Banerjee, Avirup& Malempati, Suman& Stenzel, Peter…[et al.]. 2015. A Patient-Derived Xenograft Model of Parameningeal Embryonal Rhabdomyosarcoma for Preclinical Studies. Complexity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1076103
Modern Language Association (MLA)
Hooper, Jody E.…[et al.]. A Patient-Derived Xenograft Model of Parameningeal Embryonal Rhabdomyosarcoma for Preclinical Studies. Complexity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1076103
American Medical Association (AMA)
Hooper, Jody E.& Cantor, Emma L.& Ehlen, Macgregor S.& Banerjee, Avirup& Malempati, Suman& Stenzel, Peter…[et al.]. A Patient-Derived Xenograft Model of Parameningeal Embryonal Rhabdomyosarcoma for Preclinical Studies. Complexity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1076103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076103