Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review
Joint Authors
Isohanni, Matti
Jääskeläinen, Erika
Haapea, Marianne
Rautio, Nina
Juola, Pauliina
Penttilä, Matti
Nordström, Tanja
Rissanen, Ina
Husa, Anja
Keskinen, Emmi
Marttila, Riikka
Filatova, Svetlana
Paaso, Tiina-Mari
Koivukangas, Jenni
Moilanen, Kristiina
Miettunen, Jouko
Source
Schizophrenia Research and Treatment
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Birth cohort designs are useful in studying adult disease trajectories and outcomes, such as schizophrenia.
We review the schizophrenia research performed in the Northern Finland Birth Cohort 1966 (NFBC 1966), which includes 10,934 individuals living in Finland at 16 years of age who have been monitored since each mother’s mid-pregnancy.
By the age of 44, 150 (1.4%) had developed schizophrenia.
There are 77 original papers on schizophrenia published from the NFBC 1966.
The early studies have found various risk factors for schizophrenia, especially related to pregnancy and perinatal phase.
Psychiatric and somatic outcomes were heterogeneous, but relatively poor.
Mortality in schizophrenia is high, especially due to suicides.
Several early predictors of outcomes have also been found.
Individuals with schizophrenia have alterations in brain morphometry and neurocognition, and our latest studies have found that the use of high lifetime doses of antipsychotics associated with these changes.
The schizophrenia research in the NFBC 1966 has been especially active for 20 years, the prospective study design and long follow-up enabling several clinically and epidemiologically important findings.
When compared to other birth cohorts, the research in the NFBC 1966 has offered also unique findings on course and outcome of schizophrenia.
American Psychological Association (APA)
Jääskeläinen, Erika& Haapea, Marianne& Rautio, Nina& Juola, Pauliina& Penttilä, Matti& Nordström, Tanja…[et al.]. 2015. Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review. Schizophrenia Research and Treatment،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1076116
Modern Language Association (MLA)
Jääskeläinen, Erika…[et al.]. Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review. Schizophrenia Research and Treatment No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1076116
American Medical Association (AMA)
Jääskeläinen, Erika& Haapea, Marianne& Rautio, Nina& Juola, Pauliina& Penttilä, Matti& Nordström, Tanja…[et al.]. Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review. Schizophrenia Research and Treatment. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1076116
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076116