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The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis
Joint Authors
Marra, Kacey Gribbin
Schweizer, Riccardo
Tsuji, Wakako
Gorantla, Vijay S.
Rubin, J. Peter
Plock, Jan A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
17
Abstract EN
Conventional breast cancer extirpation involves resection of parts of or the whole gland, resulting in asymmetry and disfiguration.
Given the unsatisfactory aesthetic outcomes, patients often desire postmastectomy reconstructive procedures.
Autologous fat grafting has been proposed for reconstructive purposes for decades to restore form and anatomy after mastectomy.
Fat has the inherent advantage of being autologous tissue and the most natural-appearing filler, but given its inconsistent engraftment and retention rates, it lacks reliability.
Implementation of autologous fat grafts with cellular adjuncts, such as multipotent adipose-derived stem cells (ADSCs), has shown promising results.
However, it is pertinent and critical to question whether these cells could promote any residual tumor cells to proliferate, differentiate, or metastasize or even induce de novo carcinogenesis.
Thus far, preclinical and clinical study findings are discordant.
A trend towards potential promotion of both breast cancer growth and invasion by ADSCs found in basic science studies was indeed not confirmed in clinical trials.
Whether experimental findings eventually correlate with or will be predictive of clinical outcomes remains unclear.
Herein, we aimed to concisely review current experimental findings on the interaction of mesenchymal stem cells and breast cancer, mainly focusing on ADSCs as a promising tool for regenerative medicine, and discuss the implications in clinical translation.
American Psychological Association (APA)
Schweizer, Riccardo& Tsuji, Wakako& Gorantla, Vijay S.& Marra, Kacey Gribbin& Rubin, J. Peter& Plock, Jan A.. 2015. The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis. Stem Cells International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1076123
Modern Language Association (MLA)
Schweizer, Riccardo…[et al.]. The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis. Stem Cells International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1076123
American Medical Association (AMA)
Schweizer, Riccardo& Tsuji, Wakako& Gorantla, Vijay S.& Marra, Kacey Gribbin& Rubin, J. Peter& Plock, Jan A.. The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1076123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076123