Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis
Joint Authors
Riedel, C. A.
Kurte, Mónica
Bravo-Alegría, Javiera
Torres, Alexander
Carrasco, Vania
Ibáñez, Cristina
Vega-Letter, Ana María
Fernández-O’Ryan, Catalina
Irarrázabal, Carlos E.
Figueroa, Fernando E.
Fuentealba, Rodrigo A.
Carrión, Flavio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-09
Country of Publication
Egypt
No. of Pages
14
Abstract EN
Potent immunosuppressive and regenerative properties of mesenchymal stem cells (MSCs) position them as a novel therapy for autoimmune diseases.
This research examines the therapeutic effect of MSCs administration at different disease stages in experimental autoimmune encephalomyelitis (EAE).
Classical and atypical scores of EAE, associated with Th1 and Th17 response, respectively, and also Treg lymphocytes, were evaluated.
MSCs administration at the onset (EAE+MSConset) induced an important amelioration of the clinical signs and less lasting effect at the peak of EAE (EAE+MSCpeak).
No effect was observed when MSCs were applied after EAE stabilization (EAE+MSClate).
Surprisingly, EAE atypical signs were detected in EAE+MSCpeak and EAE+MSClate mice.
However, no correlation was found in Th17/Th1 ratio.
Interestingly, regardless of time administration, MSCs significantly reduced IL-6 and also T-bet, RORγT, and Foxp3 mRNA levels in brain samples of EAE mice.
The downregulation of IL-6 could restore the well-functioning of the blood-brain barrier of EAE mice, correlated with a decreased number of brain infiltrating leukocytes.
These results suggest that the inflammatory status is important to be considered for administering MSCs in autoimmune pathologies, leading to a further research to clarify the effect of MSCs for multiple sclerosis.
American Psychological Association (APA)
Kurte, Mónica& Bravo-Alegría, Javiera& Torres, Alexander& Carrasco, Vania& Ibáñez, Cristina& Vega-Letter, Ana María…[et al.]. 2015. Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis. Stem Cells International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076127
Modern Language Association (MLA)
Kurte, Mónica…[et al.]. Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis. Stem Cells International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1076127
American Medical Association (AMA)
Kurte, Mónica& Bravo-Alegría, Javiera& Torres, Alexander& Carrasco, Vania& Ibáñez, Cristina& Vega-Letter, Ana María…[et al.]. Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076127