Glioblastoma Circulating Cells: Reality, Trap or Illusion?
Joint Authors
Lombard, A.
Goffart, N.
Rogister, Bernard
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-20
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Metastases are the hallmark of cancer.
This event is in direct relationship with the ability of cancer cells to leave the tumor mass and travel long distances within the bloodstream and/or lymphatic vessels.
Glioblastoma multiforme (GBM), the most frequent primary brain neoplasm, is mainly characterized by a dismal prognosis.
The usual fatal issue for GBM patients is a consequence of local recurrence that is observed most of the time without any distant metastases.
However, it has recently been documented that GBM cells could be isolated from the bloodstream in several studies.
This observation raises the question of the possible involvement of glioblastoma-circulating cells in GBM deadly recurrence by a “homing metastasis” process.
Therefore, we think it is important to review the already known molecular mechanisms underlying circulating tumor cells (CTC) specific properties, emphasizing their epithelial to mesenchymal transition (EMT) abilities and their possible involvement in tumor initiation.
The idea is here to review these mechanisms and speculate on how relevant they could be applied in the forthcoming battles against GBM.
American Psychological Association (APA)
Lombard, A.& Goffart, N.& Rogister, Bernard. 2015. Glioblastoma Circulating Cells: Reality, Trap or Illusion?. Stem Cells International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076145
Modern Language Association (MLA)
Lombard, A.…[et al.]. Glioblastoma Circulating Cells: Reality, Trap or Illusion?. Stem Cells International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1076145
American Medical Association (AMA)
Lombard, A.& Goffart, N.& Rogister, Bernard. Glioblastoma Circulating Cells: Reality, Trap or Illusion?. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076145