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Preliminary In Vitro Assessment of Stem Cell Compatibility with Cross-Linked Poly(ε-caprolactone urethane) Scaffolds Designed through High Internal Phase Emulsions
Joint Authors
Changotade, Sylvie
Radu Bostan, Gabriela
Consalus, Anne
Poirier, Florence
Peltzer, Juliette
Lataillade, Jean-Jacques
Lutomski, Didier
Rohman, Géraldine
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-28
Country of Publication
Egypt
No. of Pages
8
Abstract EN
By using a high internal phase emulsion process, elastomeric poly(ε-caprolactone urethane) (PCLU) scaffolds were designed with pores size ranging from below 150 μm to 1800 μm and a porosity of 86% making them suitable for bone tissue engineering applications.
Moreover, the pores appeared to be excellently interconnected, promoting cellularization and future bone ingrowth.
This study evaluated the in vitro cytotoxicity of the PCLU scaffolds towards human mesenchymal stem cells (hMSCs) through the evaluation of cell viability and metabolic activity during extract test and indirect contact test at the beginning of the scaffold lifetime.
Both tests demonstrated that PCLU scaffolds did not induce any cytotoxic response.
Finally, direct interaction of hMSCs and PCLU scaffolds showed that PCLU scaffolds were suitable for supporting the hMSCs adhesion and that the cells were well spread over the pore walls.
We conclude that PCLU scaffolds may be a good candidate for bone tissue regeneration applications using hMSCs.
American Psychological Association (APA)
Changotade, Sylvie& Radu Bostan, Gabriela& Consalus, Anne& Poirier, Florence& Peltzer, Juliette& Lataillade, Jean-Jacques…[et al.]. 2015. Preliminary In Vitro Assessment of Stem Cell Compatibility with Cross-Linked Poly(ε-caprolactone urethane) Scaffolds Designed through High Internal Phase Emulsions. Stem Cells International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076179
Modern Language Association (MLA)
Changotade, Sylvie…[et al.]. Preliminary In Vitro Assessment of Stem Cell Compatibility with Cross-Linked Poly(ε-caprolactone urethane) Scaffolds Designed through High Internal Phase Emulsions. Stem Cells International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1076179
American Medical Association (AMA)
Changotade, Sylvie& Radu Bostan, Gabriela& Consalus, Anne& Poirier, Florence& Peltzer, Juliette& Lataillade, Jean-Jacques…[et al.]. Preliminary In Vitro Assessment of Stem Cell Compatibility with Cross-Linked Poly(ε-caprolactone urethane) Scaffolds Designed through High Internal Phase Emulsions. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076179