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Physical Activity Increases the Total Number of Bone-Marrow-Derived Mesenchymal Stem Cells, Enhances Their Osteogenic Potential, and Inhibits Their Adipogenic Properties
Joint Authors
Śmieszek, Agnieszka
Marędziak, Monika
Chrząstek, Klaudia
Basinska, Katarzyna
Marycz, Krzysztof
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Aging and sedentary lifestyle are common nowadays and are associated with the increasing number of chronic diseases.
Thus, physical activity is recommended as one of three healthy behavior factors that play a crucial role in health prophylaxis.
In the present study, we were interested whether physical activity influences the number and potential of bone-marrow-derived mesenchymal stem cells BMMSCs.
In this study, four-week-old male C57Bl/6 mice were trained on a treadmill at progressive speeds over a 5-week period.
Comparisons made between exercised (EX) and sedentary animal groups revealed (i) significantly higher number of MSCs in EX animals, (ii) elevated alkaline phosphatase (ALP) activity, (iii) increased level of osteopontin (OPN) and osteocalcin (OCL), and (iv) reduced marrow cavity fat.
The results obtained support the thesis that EX may play a substantial role in the regeneration of mesenchymal tissues.
Therefore, EX may represent a novel, nonpharmacological strategy of slowing down age-related decline of the musculoskeletal functions.
American Psychological Association (APA)
Marędziak, Monika& Śmieszek, Agnieszka& Chrząstek, Klaudia& Basinska, Katarzyna& Marycz, Krzysztof. 2015. Physical Activity Increases the Total Number of Bone-Marrow-Derived Mesenchymal Stem Cells, Enhances Their Osteogenic Potential, and Inhibits Their Adipogenic Properties. Stem Cells International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076197
Modern Language Association (MLA)
Marędziak, Monika…[et al.]. Physical Activity Increases the Total Number of Bone-Marrow-Derived Mesenchymal Stem Cells, Enhances Their Osteogenic Potential, and Inhibits Their Adipogenic Properties. Stem Cells International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1076197
American Medical Association (AMA)
Marędziak, Monika& Śmieszek, Agnieszka& Chrząstek, Klaudia& Basinska, Katarzyna& Marycz, Krzysztof. Physical Activity Increases the Total Number of Bone-Marrow-Derived Mesenchymal Stem Cells, Enhances Their Osteogenic Potential, and Inhibits Their Adipogenic Properties. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076197