Applications of Induced Pluripotent Stem Cells in Studying the Neurodegenerative Diseases
Joint Authors
Wan, Wenbin
Kalionis, Bill
Cao, Lan
Xia, Shi-Jin
Tai, Xiantao
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-09
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons.
Incurable neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) show dramatic rising trends particularly in the advanced age groups.
However, the underlying mechanisms are not yet fully elucidated, and to date there are no biomarkers for early detection or effective treatments for the underlying causes of these diseases.
Furthermore, due to species variation and differences between animal models (e.g., mouse transgenic and knockout models) of neurodegenerative diseases, substantial debate focuses on whether animal and cell culture disease models can correctly model the condition in human patients.
In 2006, Yamanaka of Kyoto University first demonstrated a novel approach for the preparation of induced pluripotent stem cells (iPSCs), which displayed similar pluripotency potential to embryonic stem cells (ESCs).
Currently, iPSCs studies are permeating many sectors of disease research.
Patient sample-derived iPSCs can be used to construct patient-specific disease models to elucidate the pathogenic mechanisms of disease development and to test new therapeutic strategies.
Accordingly, the present review will focus on recent progress in iPSC research in the modeling of neurodegenerative disorders and in the development of novel therapeutic options.
American Psychological Association (APA)
Wan, Wenbin& Cao, Lan& Kalionis, Bill& Xia, Shi-Jin& Tai, Xiantao. 2015. Applications of Induced Pluripotent Stem Cells in Studying the Neurodegenerative Diseases. Stem Cells International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076198
Modern Language Association (MLA)
Wan, Wenbin…[et al.]. Applications of Induced Pluripotent Stem Cells in Studying the Neurodegenerative Diseases. Stem Cells International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1076198
American Medical Association (AMA)
Wan, Wenbin& Cao, Lan& Kalionis, Bill& Xia, Shi-Jin& Tai, Xiantao. Applications of Induced Pluripotent Stem Cells in Studying the Neurodegenerative Diseases. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076198