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Alterations in the Secretome of Clinically Relevant Preparations of Adipose-Derived Mesenchymal Stem Cells Cocultured with Hyaluronan
Joint Authors
Succar, Peter
Breen, Edmond J.
Kuah, Donald
Herbert, Benjamin R.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-15
Country of Publication
Egypt
No. of Pages
16
Abstract EN
Osteoarthritis (OA) can be a debilitating degenerative disease and is the most common form of arthritic disease.
There is a general consensus that current nonsurgical therapies are insufficient for younger OA sufferers who are not candidates for knee arthroplasties.
Adipose-derived mesenchymal stem cells (MSCs) therapy for the treatment of OA can slow disease progression and lead to neocartilage formation.
The mechanism of action is secretion driven.
Current clinical preparations from adipose tissue for the treatment of OA include autologous stromal vascular fraction (SVF), SVF plus mature adipocytes, and culture-purified MSCs.
Herein we have combined these human adipose-derived preparations with Hyaluronan (Hylan G-F 20: Synvisc) in vitro and measured alterations in cytokine profile.
SVF plus mature adipocytes showed the greatest decreased in the proinflammatory cytokines IL-1β, IFN-γ, and VEGF.
MCP-1 and MIP-1α decreased substantially in the SVF preparations but not the purified MSCs.
The purified MSC preparation was the only one to show increase in MIF.
Overall the SVF plus mature adipocytes preparation may be most suited of all the preparations for combination with HA for the treatment of OA, based on the alterations of heavily implicated cytokines in OA disease progression.
This will require further validation using in vivo models.
American Psychological Association (APA)
Succar, Peter& Breen, Edmond J.& Kuah, Donald& Herbert, Benjamin R.. 2015. Alterations in the Secretome of Clinically Relevant Preparations of Adipose-Derived Mesenchymal Stem Cells Cocultured with Hyaluronan. Stem Cells International،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1076202
Modern Language Association (MLA)
Succar, Peter…[et al.]. Alterations in the Secretome of Clinically Relevant Preparations of Adipose-Derived Mesenchymal Stem Cells Cocultured with Hyaluronan. Stem Cells International No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1076202
American Medical Association (AMA)
Succar, Peter& Breen, Edmond J.& Kuah, Donald& Herbert, Benjamin R.. Alterations in the Secretome of Clinically Relevant Preparations of Adipose-Derived Mesenchymal Stem Cells Cocultured with Hyaluronan. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1076202
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076202