EGFR Amplification and Glioblastoma Stem-Like Cells
Joint Authors
Liffers, Katrin
Lamszus, Katrin
Schulte, Alexander
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-02
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Glioblastoma (GBM), the most common malignant brain tumor in adults, contains a subpopulation of cells with a stem-like phenotype (GS-cells).
GS-cells can be maintained in vitro using serum-free medium supplemented with epidermal growth factor, basic fibroblast growth factor-2, and heparin.
However, this method does not conserve amplification of the Epidermal Growth Factor Receptor (EGFR) gene, which is present in over 50% of all newly diagnosed GBM cases.
GS-cells with retained EGFR amplification could overcome the limitations of current in vitro model systems and contribute significantly to preclinical research on EGFR-targeted therapy.
This review recapitulates recent methodological approaches to expand stem-like cells from GBM with different EGFR status in order to maintain EGFR-dependent intratumoral heterogeneity in vitro.
Further, it will summarize the current knowledge about the impact of EGFR amplification and overexpression on the stem-like phenotype of GBM-derived GS-cells and different approaches to target the EGFR-dependent GS-cell compartment of GBM.
American Psychological Association (APA)
Liffers, Katrin& Lamszus, Katrin& Schulte, Alexander. 2015. EGFR Amplification and Glioblastoma Stem-Like Cells. Stem Cells International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076203
Modern Language Association (MLA)
Liffers, Katrin…[et al.]. EGFR Amplification and Glioblastoma Stem-Like Cells. Stem Cells International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1076203
American Medical Association (AMA)
Liffers, Katrin& Lamszus, Katrin& Schulte, Alexander. EGFR Amplification and Glioblastoma Stem-Like Cells. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076203