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Hedgehog and Resident Vascular Stem Cell Fate
Joint Authors
Mooney, Ciaran J.
Hakimjavadi, Roya
Fitzpatrick, Emma
Kennedy, Eimear
Walls, Dermot
Morrow, David
Redmond, Eileen M.
Cahill, Paul A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-06
Country of Publication
Egypt
No. of Pages
16
Abstract EN
The Hedgehog pathway is a pivotal morphogenic driver during embryonic development and a key regulator of adult stem cell self-renewal.
The discovery of resident multipotent vascular stem cells and adventitial progenitors within the vessel wall has transformed our understanding of the origin of medial and neointimal vascular smooth muscle cells (SMCs) during vessel repair in response to injury, lesion formation, and overall disease progression.
This review highlights the importance of components of the Hh and Notch signalling pathways within the medial and adventitial regions of adult vessels, their recapitulation following vascular injury and disease progression, and their putative role in the maintenance and differentiation of resident vascular stem cells to vascular lineages from discrete niches within the vessel wall.
American Psychological Association (APA)
Mooney, Ciaran J.& Hakimjavadi, Roya& Fitzpatrick, Emma& Kennedy, Eimear& Walls, Dermot& Morrow, David…[et al.]. 2015. Hedgehog and Resident Vascular Stem Cell Fate. Stem Cells International،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1076214
Modern Language Association (MLA)
Mooney, Ciaran J.…[et al.]. Hedgehog and Resident Vascular Stem Cell Fate. Stem Cells International No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1076214
American Medical Association (AMA)
Mooney, Ciaran J.& Hakimjavadi, Roya& Fitzpatrick, Emma& Kennedy, Eimear& Walls, Dermot& Morrow, David…[et al.]. Hedgehog and Resident Vascular Stem Cell Fate. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1076214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076214