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Atlas of Cellular Dynamics during Zebrafish Adult Kidney Regeneration
Joint Authors
McCampbell, Kristen K.
Springer, Kristin N.
Wingert, Rebecca A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
19
Abstract EN
The zebrafish is a useful animal model to study the signaling pathways that orchestrate kidney regeneration, as its renal nephrons are simple, yet they maintain the biological complexity inherent to that of higher vertebrate organisms including mammals.
Recent studies have suggested that administration of the aminoglycoside antibiotic gentamicin in zebrafish mimics human acute kidney injury (AKI) through the induction of nephron damage, but the timing and details of critical phenotypic events associated with the regeneration process, particularly in existing nephrons, have not been characterized.
Here, we mapped the temporal progression of cellular and molecular changes that occur during renal epithelial regeneration of the proximal tubule in the adult zebrafish using a platform of histological and expression analysis techniques.
This work establishes the timing of renal cell death after gentamicin injury, identifies proliferative compartments within the kidney, and documents gene expression changes associated with the regenerative response of proliferating cells.
These data provide an important descriptive atlas that documents the series of events that ensue after damage in the zebrafish kidney, thus availing a valuable resource for the scientific community that can facilitate the implementation of zebrafish research to delineate the mechanisms that control renal regeneration.
American Psychological Association (APA)
McCampbell, Kristen K.& Springer, Kristin N.& Wingert, Rebecca A.. 2015. Atlas of Cellular Dynamics during Zebrafish Adult Kidney Regeneration. Stem Cells International،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1076263
Modern Language Association (MLA)
McCampbell, Kristen K.…[et al.]. Atlas of Cellular Dynamics during Zebrafish Adult Kidney Regeneration. Stem Cells International No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1076263
American Medical Association (AMA)
McCampbell, Kristen K.& Springer, Kristin N.& Wingert, Rebecca A.. Atlas of Cellular Dynamics during Zebrafish Adult Kidney Regeneration. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1076263
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076263