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Human Umbilical Cord Mesenchymal Stem Cells: A New Therapeutic Option for Tooth Regeneration
Joint Authors
Chen, Yuanwei
Yu, Yongchun
Chen, Lin
Ye, Lanfeng
Cui, Junhui
Sun, Quan
Li, Kaide
Li, Zhiyong
Liu, Lei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-02
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Tooth regeneration is considered to be an optimistic approach to replace current treatments for tooth loss.
It is important to determine the most suitable seed cells for tooth regeneration.
Recently, human umbilical cord mesenchymal stem cells (hUCMSCs) have been regarded as a promising candidate for tissue regeneration.
However, it has not been reported whether hUCMSCs can be employed in tooth regeneration.
Here, we report that hUCMSCs can be induced into odontoblast-like cells in vitro and in vivo.
Induced hUCMSCs expressed dentin-related proteins including dentin sialoprotein (DSP) and dentin matrix protein-1 (DMP-1), and their gene expression levels were similar to those in native pulp tissue cells.
Moreover, DSP- and DMP-1-positive calcifications were observed after implantation of hUCMSCs in vivo.
These findings reveal that hUCMSCs have an odontogenic differentiation potency to differentiate to odontoblast-like cells with characteristic deposition of dentin-like matrix in vivo.
This study clearly demonstrates hUCMSCs as an alternative therapeutic cell source for tooth regeneration.
American Psychological Association (APA)
Chen, Yuanwei& Yu, Yongchun& Chen, Lin& Ye, Lanfeng& Cui, Junhui& Sun, Quan…[et al.]. 2015. Human Umbilical Cord Mesenchymal Stem Cells: A New Therapeutic Option for Tooth Regeneration. Stem Cells International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076268
Modern Language Association (MLA)
Chen, Yuanwei…[et al.]. Human Umbilical Cord Mesenchymal Stem Cells: A New Therapeutic Option for Tooth Regeneration. Stem Cells International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1076268
American Medical Association (AMA)
Chen, Yuanwei& Yu, Yongchun& Chen, Lin& Ye, Lanfeng& Cui, Junhui& Sun, Quan…[et al.]. Human Umbilical Cord Mesenchymal Stem Cells: A New Therapeutic Option for Tooth Regeneration. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076268