Comparative Investigation of Human Amniotic Epithelial Cells and Mesenchymal Stem Cells for Application in Bone Tissue Engineering
Joint Authors
Si, Jiawen
Dai, Jiewen
Zhang, Jianjun
Liu, Sha
Gu, Jing
Shi, Jun
Shen, Steve G. F.
Guo, Lihe
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-05
Country of Publication
Egypt
No. of Pages
14
Abstract EN
Emerging evidence suggests amniotic epithelial cells (AECs) as a promising source of progenitor cells in regenerative medicine and bone tissue engineering.
However, investigations comparing the regenerative properties of AECs with other sources of stem cells are particularly needed before the feasibility of AECs in bone tissue engineering can be determined.
This study aimed to compare human amniotic epithelial cells (hAECs), human bone marrow mesenchymal stem cells (hBMSCs), and human amniotic fluid derived mesenchymal stem cells (hAFMSCs) in terms of their morphology, proliferation, immunophenotype profile, and osteogenic capacity in vitro and in vivo.
Not only greatly distinguished by cell morphology and proliferation, hAECs, hAFMSCs, and hBMSCs exhibited remarkably different signature regarding immunophenotypical profile.
Microarray analysis revealed a different expression profile of genes involved in ossification along the three cell sources, highlighting the impact of different anatomical origin and molecular response to osteogenic induction on the final tissue-forming potential.
Furthermore, our data indicated a potential role of FOXC2 in early osteogenic commitment.
American Psychological Association (APA)
Si, Jiawen& Dai, Jiewen& Zhang, Jianjun& Liu, Sha& Gu, Jing& Shi, Jun…[et al.]. 2015. Comparative Investigation of Human Amniotic Epithelial Cells and Mesenchymal Stem Cells for Application in Bone Tissue Engineering. Stem Cells International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076274
Modern Language Association (MLA)
Si, Jiawen…[et al.]. Comparative Investigation of Human Amniotic Epithelial Cells and Mesenchymal Stem Cells for Application in Bone Tissue Engineering. Stem Cells International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1076274
American Medical Association (AMA)
Si, Jiawen& Dai, Jiewen& Zhang, Jianjun& Liu, Sha& Gu, Jing& Shi, Jun…[et al.]. Comparative Investigation of Human Amniotic Epithelial Cells and Mesenchymal Stem Cells for Application in Bone Tissue Engineering. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076274