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What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?
Joint Authors
Graca, Luis
Bárcia, R. N.
Santos, J. M.
Filipe, M.
Teixeira, M.
Martins, J. P.
Almeida, J.
Água-Doce, A.
Almeida, S. C. P.
Varela, A.
Pohl, S.
Dittmar, K. E. J.
Calado, S.
Simões, S. I.
Gaspar, M. M.
Cruz, M. E. M.
Lindenmaier, W.
Cruz, H.
Cruz, P. E.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-12
Country of Publication
Egypt
No. of Pages
14
Abstract EN
MSCs derived from the umbilical cord tissue, termed UCX, were investigated for their immunomodulatory properties and compared to bone marrow-derived MSCs (BM-MSCs), the gold-standard in immunotherapy.
Immunogenicity and immunosuppression were assessed by mixed lymphocyte reactions, suppression of lymphocyte proliferation and induction of regulatory T cells.
Results showed that UCX were less immunogenic and showed higher immunosuppression activity than BM-MSCs.
Further, UCX did not need prior activation or priming to exert their immunomodulatory effects.
This was further corroborated in vivo in a model of acute inflammation.
To elucidate the potency differences observed between UCX and BM-MSCs, gene expression related to immune modulation was analysed in both cell types.
Several gene expression profile differences were found between UCX and BM-MSCs, namely decreased expression of HLA-DRA, HO-1, IGFBP1, 4 and 6, ILR1, IL6R and PTGES and increased expression of CD200, CD273, CD274, IL1B, IL-8, LIF and TGFB2.
The latter were confirmed at the protein expression level.
Overall, these results show that UCX seem to be naturally more potent immunosuppressors and less immunogenic than BM-MSCs.
We propose that these differences may be due to increased levels of immunomodulatory surface proteins such as CD200, CD273, CD274 and cytokines such as IL1β, IL-8, LIF and TGFβ2.
American Psychological Association (APA)
Bárcia, R. N.& Santos, J. M.& Filipe, M.& Teixeira, M.& Martins, J. P.& Almeida, J.…[et al.]. 2015. What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?. Stem Cells International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076280
Modern Language Association (MLA)
Bárcia, R. N.…[et al.]. What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?. Stem Cells International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1076280
American Medical Association (AMA)
Bárcia, R. N.& Santos, J. M.& Filipe, M.& Teixeira, M.& Martins, J. P.& Almeida, J.…[et al.]. What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076280