Concise Review: Are Stimulated Somatic Cells Truly Reprogrammed into an ESiPS-Like Pluripotent State? Better Understanding by Ischemia-Induced Multipotent Stem Cells in a Mouse Model of Cerebral Infarction
Joint Authors
Nakagomi, Takayuki
Nakano-Doi, Akiko
Narita, Aya
Matsuyama, Tomohiro
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-06
Country of Publication
Egypt
No. of Pages
6
Abstract EN
Following the discovery of pluripotent stem (PS) cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells, there has been a great hope that injured tissues can be repaired by transplantation of ES/iPS-derived various specific types of cells such as neural stem cells (NSCs).
Although PS cells can be induced by ectopic expression of Yamanaka’s factors, it is known that several stimuli such as ischemia/hypoxia can increase the stemness of somatic cells via reprogramming.
This suggests that endogenous somatic cells acquire stemness during natural regenerative processes following injury.
In this study, we describe whether somatic cells are converted into pluripotent stem cells by pathological stimuli without ectopic expression of reprogramming factors based on the findings of ischemia-induced multipotent stem cells in a mouse model of cerebral infarction.
American Psychological Association (APA)
Nakagomi, Takayuki& Nakano-Doi, Akiko& Narita, Aya& Matsuyama, Tomohiro. 2015. Concise Review: Are Stimulated Somatic Cells Truly Reprogrammed into an ESiPS-Like Pluripotent State? Better Understanding by Ischemia-Induced Multipotent Stem Cells in a Mouse Model of Cerebral Infarction. Stem Cells International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1076301
Modern Language Association (MLA)
Nakagomi, Takayuki…[et al.]. Concise Review: Are Stimulated Somatic Cells Truly Reprogrammed into an ESiPS-Like Pluripotent State? Better Understanding by Ischemia-Induced Multipotent Stem Cells in a Mouse Model of Cerebral Infarction. Stem Cells International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1076301
American Medical Association (AMA)
Nakagomi, Takayuki& Nakano-Doi, Akiko& Narita, Aya& Matsuyama, Tomohiro. Concise Review: Are Stimulated Somatic Cells Truly Reprogrammed into an ESiPS-Like Pluripotent State? Better Understanding by Ischemia-Induced Multipotent Stem Cells in a Mouse Model of Cerebral Infarction. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1076301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076301