Bone Marrow-Derived Multipotent Stromal Cells Promote Myocardial Fibrosis and Reverse Remodeling of the Left Ventricle
Joint Authors
Fatkhudinov, Timur
Bolshakova, Galina
Arutyunyan, Irina
Elchaninov, Andrey
Makarov, Andrey
Kananykhina, Evgeniya
Khokhlova, Oksana
Murashev, Arkady
Glinkina, Valeria
Goldshtein, Dmitry
Sukhikh, Gennady
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-21
Country of Publication
Egypt
No. of Pages
16
Abstract EN
Cell therapy is increasingly recognized as a beneficial practice in various cardiac conditions, but its fundamentals remain largely unclear.
The fates of transplanted multipotent stromal cells in postinfarction cardiac microenvironments are particularly understudied.
To address this issue, labeled multipotent stromal cells were infused into rat myocardium at day 30 after myocardial infarction, against the background of postinfarction cardiosclerosis.
Therapeutic effects of the transplantation were assessed by an exercise tolerance test.
Histological examination at 14 or 30 days after the transplantation was conducted by means of immunostaining and quantitative image analysis.
An improvement in the functional status of the cardiovascular system was observed after both the autologous and the allogeneic transplantations.
Location of the label-positive cells within the heart was restricted to the affected part of myocardium.
The transplanted cells could give rise to fibroblasts or myofibroblasts but not to cardiac myocytes or blood vessel cells.
Both types of transplantation positively influenced scarring processes, and no expansion of fibrosis to border myocardium was observed.
Left ventricular wall thickening associated with reduced dilatation index was promoted by transplantation of the autologous cells.
According to the results, multipotent stromal cell transplantation prevents adverse remodeling and stimulates left ventricular reverse remodeling.
American Psychological Association (APA)
Fatkhudinov, Timur& Bolshakova, Galina& Arutyunyan, Irina& Elchaninov, Andrey& Makarov, Andrey& Kananykhina, Evgeniya…[et al.]. 2015. Bone Marrow-Derived Multipotent Stromal Cells Promote Myocardial Fibrosis and Reverse Remodeling of the Left Ventricle. Stem Cells International،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1076338
Modern Language Association (MLA)
Fatkhudinov, Timur…[et al.]. Bone Marrow-Derived Multipotent Stromal Cells Promote Myocardial Fibrosis and Reverse Remodeling of the Left Ventricle. Stem Cells International No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1076338
American Medical Association (AMA)
Fatkhudinov, Timur& Bolshakova, Galina& Arutyunyan, Irina& Elchaninov, Andrey& Makarov, Andrey& Kananykhina, Evgeniya…[et al.]. Bone Marrow-Derived Multipotent Stromal Cells Promote Myocardial Fibrosis and Reverse Remodeling of the Left Ventricle. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1076338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076338