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Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo
Joint Authors
Yin, Lihua
Cheng, Wenxiao
Qin, Zishun
Yu, Hongdou
Yu, Zhanhai
Zhong, Mei
Sun, Kemo
Zhang, Wei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-20
Country of Publication
Egypt
No. of Pages
9
Abstract EN
This study is to explore the osteogenesis potential of the human periodontal ligament stem cells (hPDLSCs) induced by naringin in vitro and in vitro.
The results confirmed that 1 μM naringin performs the best effect and a collection of bone-related genes (RUNX2, COL1A2, OPN, and OCN) had significantly higher expression levels compared to the control group.
Furthermore, a typical trabecular structure was observed in vivo, surrounded by a large amount of osteoblasts.
These results demonstrated that naringin, at a concentration of 1 μM, can efficiently promote the proliferation and differentiation of hPDLSCs both in vitro and in vivo.
American Psychological Association (APA)
Yin, Lihua& Cheng, Wenxiao& Qin, Zishun& Yu, Hongdou& Yu, Zhanhai& Zhong, Mei…[et al.]. 2015. Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo. Stem Cells International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076341
Modern Language Association (MLA)
Yin, Lihua…[et al.]. Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo. Stem Cells International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1076341
American Medical Association (AMA)
Yin, Lihua& Cheng, Wenxiao& Qin, Zishun& Yu, Hongdou& Yu, Zhanhai& Zhong, Mei…[et al.]. Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076341