Characterization of Nestin, a Selective Marker for Bone Marrow Derived Mesenchymal Stem Cells
Joint Authors
Zeng, Xin
Xie, Liang
Hu, Jing
Chen, Qian-ming
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-06
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into multiple cell lineages and contributing to tissue repair and regeneration.
Characterization of the physiological function of MSCs has been largely hampered by lack of unique markers.
Nestin, originally found in neuroepithelial stem cells, is an intermediate filament protein expressed in the early stages of development.
Increasing studies have shown a particular association between Nestin and MSCs.
Nestin could characterize a subset of bone marrow perivascular MSCs which contributed to bone development and closely contacted with hematopoietic stem cells (HSCs).
Nestin expressing (Nes+) MSCs also play a role in the progression of various diseases.
However, Nes+ cells were reported to participate in angiogenesis as MSCs or endothelial progenitor cells (EPCs) in several tissues and be a heterogeneous population comprising mesenchymal cells and endothelial cells in the developing bone marrow.
In this review article, we will summarize the progress of the research on Nestin, particularly the function of Nes+ cells in bone marrow, and discuss the feasibility of using Nestin as a specific marker for MSCs.
American Psychological Association (APA)
Xie, Liang& Zeng, Xin& Hu, Jing& Chen, Qian-ming. 2015. Characterization of Nestin, a Selective Marker for Bone Marrow Derived Mesenchymal Stem Cells. Stem Cells International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076343
Modern Language Association (MLA)
Xie, Liang…[et al.]. Characterization of Nestin, a Selective Marker for Bone Marrow Derived Mesenchymal Stem Cells. Stem Cells International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1076343
American Medical Association (AMA)
Xie, Liang& Zeng, Xin& Hu, Jing& Chen, Qian-ming. Characterization of Nestin, a Selective Marker for Bone Marrow Derived Mesenchymal Stem Cells. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076343