Dynamic Network-Based Relevance Score Reveals Essential Proteins and Functional Modules in Directed Differentiation
Joint Authors
Chen, Bor-Sen
Lin, Che
Wu, Chia-Chou
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-21
Country of Publication
Egypt
No. of Pages
14
Abstract EN
The induction of stem cells toward a desired differentiation direction is required for the advancement of stem cell-based therapies.
Despite successful demonstrations of the control of differentiation direction, the effective use of stem cell-based therapies suffers from a lack of systematic knowledge regarding the mechanisms underlying directed differentiation.
Using dynamic modeling and the temporal microarray data of three differentiation stages, three dynamic protein-protein interaction networks were constructed.
The interaction difference networks derived from the constructed networks systematically delineated the evolution of interaction variations and the underlying mechanisms.
A proposed relevance score identified the essential components in the directed differentiation.
Inspection of well-known proteins and functional modules in the directed differentiation showed the plausibility of the proposed relevance score, with the higher scores of several proteins and function modules indicating their essential roles in the directed differentiation.
During the differentiation process, the proteins and functional modules with higher relevance scores also became more specific to the neuronal identity.
Ultimately, the essential components revealed by the relevance scores may play a role in controlling the direction of differentiation.
In addition, these components may serve as a starting point for understanding the systematic mechanisms of directed differentiation and for increasing the efficiency of stem cell-based therapies.
American Psychological Association (APA)
Wu, Chia-Chou& Lin, Che& Chen, Bor-Sen. 2015. Dynamic Network-Based Relevance Score Reveals Essential Proteins and Functional Modules in Directed Differentiation. Stem Cells International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076345
Modern Language Association (MLA)
Wu, Chia-Chou…[et al.]. Dynamic Network-Based Relevance Score Reveals Essential Proteins and Functional Modules in Directed Differentiation. Stem Cells International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1076345
American Medical Association (AMA)
Wu, Chia-Chou& Lin, Che& Chen, Bor-Sen. Dynamic Network-Based Relevance Score Reveals Essential Proteins and Functional Modules in Directed Differentiation. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1076345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076345