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Reprogramming with Small Molecules instead of Exogenous Transcription Factors
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-01
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Induced pluripotent stem cells (iPSCs) could be employed in the creation of patient-specific stem cells, which could subsequently be used in various basic and clinical applications.
However, current iPSC methodologies present significant hidden risks with respect to genetic mutations and abnormal expression which are a barrier in realizing the full potential of iPSCs.
A chemical approach is thought to be a promising strategy for safety and efficiency of iPSC generation.
Many small molecules have been identified that can be used in place of exogenous transcription factors and significantly improve iPSC reprogramming efficiency and quality.
Recent studies have shown that the use of small molecules results in the generation of chemically induced pluripotent stem cells from mouse embryonic fibroblast cells.
These studies might lead to new areas of stem cell research and medical applications, not only human iPSC by chemicals alone, but also safe generation of somatic stem cells for cell based clinical trials and other researches.
In this paper, we have reviewed the recent advances in small molecule approaches for the generation of iPSCs.
American Psychological Association (APA)
Lin, Tongxiang& Wu, Shouhai. 2015. Reprogramming with Small Molecules instead of Exogenous Transcription Factors. Stem Cells International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076346
Modern Language Association (MLA)
Lin, Tongxiang& Wu, Shouhai. Reprogramming with Small Molecules instead of Exogenous Transcription Factors. Stem Cells International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1076346
American Medical Association (AMA)
Lin, Tongxiang& Wu, Shouhai. Reprogramming with Small Molecules instead of Exogenous Transcription Factors. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076346