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Human Mesenchymal Stromal Cells Transplantation May Enhance or Inhibit 4T1 Murine Breast Adenocarcinoma through Different Approaches
Joint Authors
Martins, M. T.
Jazedje, T.
Ribeiro, A. L.
Pellati, M.
de Siqueira Bueno, H. M.
Nagata, G.
Rodrigues, E. G.
Zatz, Mayana
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
11
Abstract EN
The use of Mesenchymal Stromal Cells (MSCs) aiming to treat cancer has shown very contradictory results.
In an attempt to clarify the contradictory results reported in the literature and the possible role of human fallopian tube Mesenchymal Stromal Cells (htMSCs) against breast cancer, the aim of this study was to evaluate the clinical effect of htMSCs in murine mammary adenocarcinoma using two different approaches: (1) coinjections of htMSCs and 4T1 murine tumor cell lineage and (2) injections of htMSCs in mice at the initial stage of mammary adenocarcinoma development.
Coinjected animals had a more severe course of the disease and a reduced survival, while tumor-bearing animals treated with 2 intraperitoneal injections of 106 htMSCs showed significantly reduced tumor growth and increased lifespan as compared with control animals.
Coculture of htMSCs and 4T1 tumor cells revealed an increase in IL-8 and MCP-1 and decreased VEGF production.
For the first time, we show that MSCs isolated from a single source and donor when injected in the same animal model and tumor can lead to opposite results depending on the experimental protocol.
Also, our results demonstrated that htMSCs can have an inhibitory effect on the development of murine mammary adenocarcinoma.
American Psychological Association (APA)
Jazedje, T.& Ribeiro, A. L.& Pellati, M.& de Siqueira Bueno, H. M.& Nagata, G.& Martins, M. T.…[et al.]. 2015. Human Mesenchymal Stromal Cells Transplantation May Enhance or Inhibit 4T1 Murine Breast Adenocarcinoma through Different Approaches. Stem Cells International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076347
Modern Language Association (MLA)
Jazedje, T.…[et al.]. Human Mesenchymal Stromal Cells Transplantation May Enhance or Inhibit 4T1 Murine Breast Adenocarcinoma through Different Approaches. Stem Cells International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1076347
American Medical Association (AMA)
Jazedje, T.& Ribeiro, A. L.& Pellati, M.& de Siqueira Bueno, H. M.& Nagata, G.& Martins, M. T.…[et al.]. Human Mesenchymal Stromal Cells Transplantation May Enhance or Inhibit 4T1 Murine Breast Adenocarcinoma through Different Approaches. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076347